Publication: Optimizing the Clinical Use of Vancomycin.
dc.contributor.author | Alvarez, Rocio | |
dc.contributor.author | Lopez Cortes, Luis E | |
dc.contributor.author | Molina, Jose | |
dc.contributor.author | Cisneros, Jose M | |
dc.contributor.author | Pachon, Jeronimo | |
dc.contributor.funder | Plan Nacional de I+D+i and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases | |
dc.date.accessioned | 2023-01-25T08:30:54Z | |
dc.date.available | 2023-01-25T08:30:54Z | |
dc.date.issued | 2016 | |
dc.description.abstract | The increasing number of infections produced by beta-lactam-resistant Gram-positive bacteria and the morbidity secondary to these infections make it necessary to optimize the use of vancomycin. In 2009, the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Disease Pharmacists published specific guidelines about vancomycin dosage and monitoring. However, these guidelines have not been updated in the past 6 years. This review analyzes the new available information about vancomycin published in recent years regarding pharmacokinetics and pharmacodynamics, serum concentration monitoring, and optimal vancomycin dosing in special situations (obese people, burn patients, renal replacement therapy, among others). Vancomycin efficacy is linked to a correct dosage which should aim to reach an area under the curve (AUC)/MIC ratio of ≥400; serum trough levels of 15 to 20 mg/liter are considered a surrogate marker of an AUC/MIC ratio of ≥400 for a MIC of ≤1 mg/liter. For Staphylococcus aureus strains presenting with a MIC >1 mg/liter, an alternative agent should be considered. Vancomycin doses must be adjusted according to body weight and the plasma trough levels of the drug. Nephrotoxicity has been associated with target vancomycin trough levels above 15 mg/liter. Continuous infusion is an option, especially for patients at high risk of renal impairment or unstable vancomycin clearance. In such cases, vancomycin plasma steady-state level and creatinine monitoring are strongly indicated. | |
dc.description.version | No | |
dc.identifier.citation | Álvarez R, López Cortés LE, Molina J, Cisneros JM, Pachón J. Optimizing the Clinical Use of Vancomycin. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2601-9 | |
dc.identifier.doi | 10.1128/AAC.03147-14 | |
dc.identifier.essn | 1098-6596 | |
dc.identifier.pmc | PMC4862470 | |
dc.identifier.pmid | 26856841 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862470/pdf | |
dc.identifier.unpaywallURL | https://europepmc.org/articles/pmc4862470?pdf=render | |
dc.identifier.uri | http://hdl.handle.net/10668/9819 | |
dc.issue.number | 5 | |
dc.journal.title | Antimicrobial agents and chemotherapy | |
dc.journal.titleabbreviation | Antimicrob Agents Chemother | |
dc.language.iso | en | |
dc.organization | Instituto de Biomedicina de Sevilla-IBIS | |
dc.organization | Hospital Universitario Virgen del Rocío | |
dc.organization | Hospital Universitario Virgen Macarena | |
dc.page.number | 2601-2609 | |
dc.provenance | Realizada la curación de contenido 24/06/2025. | |
dc.publisher | American Society for Microbiology | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Review | |
dc.pubmedtype | Research Support, Non-U.S. Gov't | |
dc.relation.projectID | REIPI RD12/0015/0001 | |
dc.relation.publisherversion | https://journals.asm.org/doi/10.1128/AAC.03147-14?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Beta-lactam-resistant bacteria | |
dc.subject | Vancomycin dosage | |
dc.subject | Pharmacokinetics | |
dc.subject | Serum concentration monitoring | |
dc.subject | Nephrotoxicity | |
dc.subject | Renal replacement therapy | |
dc.subject.decs | Vancomicina | |
dc.subject.decs | Infecciones por bacterias gram-positivas | |
dc.subject.decs | Farmacocinética | |
dc.subject.decs | Nefrotoxicidad | |
dc.subject.decs | Terapia de reemplazo renal | |
dc.subject.decs | Monitorización de fármacos | |
dc.subject.mesh | Anti-Bacterial Agents | |
dc.subject.mesh | Drug Administration Schedule | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Microbial Sensitivity Tests | |
dc.subject.mesh | Staphylococcus aureus | |
dc.subject.mesh | Vancomycin | |
dc.title | Optimizing the Clinical Use of Vancomycin. | |
dc.type | review | |
dc.type.hasVersion | VoR | |
dc.volume.number | 60 | |
dspace.entity.type | Publication |
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