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Age-dependent effect of metabolic phenotypes on carotid atherosclerotic disease in coronary heart disease patients (CORDIOPREV study).

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dc.contributor.authorGutierrez-Mariscal, Francisco M
dc.contributor.authorGarcia-Rios, Antonio
dc.contributor.authorGomez-Luna, Purificacion
dc.contributor.authorFernandez-Gandara, Carolina
dc.contributor.authorCardelo, Magdalena P
dc.contributor.authorde la Cruz-Ares, Silvia
dc.contributor.authorRodriguez-Cantalejo, Fernando
dc.contributor.authorLuque, Raul M
dc.contributor.authorLeon-Acuña, Ana
dc.contributor.authorDelgado-Lista, Javier
dc.contributor.authorPerez-Martinez, Pablo
dc.contributor.authorYubero-Serrano, Elena M
dc.contributor.authorLopez-Miranda, Jose
dc.contributor.funderEASP (Escuela Andaluza de Salud Publica), Granada (Spain)
dc.contributor.funderInstituto de Salud Carlos III, Madrid, Spain
dc.date.accessioned2023-02-08T14:46:46Z
dc.date.available2023-02-08T14:46:46Z
dc.date.issued2020-04-01
dc.description.abstractAging is associated with a high risk for cardiovascular disease. The relation of obesity and risk of cardiovascular events appears to be more closely linked to certain clinical or metabolic phenotypes than to obesity itself. Our aim was to establish whether aging influenced the metabolic phenotypes regarding to cardiovascular risk, evaluated by changes in the intima media thickness-common carotid (IMT-CC), in coronary heart disease (CHD) patients. In this cross-sectional study, 1002 CHD patients were studied at entry from the CORDIOPREV study. We performed carotid ultrasound assessment to obtain their IMT-CC values. Carotid atherosclerosis was considered to exist if IMT-CC > 0.7 mm. Age determined a higher IMT-CC, regardless metabolic phenotype (all p  Our results suggest that CHD patients aged≥60 are less metabolic flexible compared to patients aged
dc.description.sponsorshipWe would like to thank the EASP (Escuela Andaluza de Salud Publica), Granada (Spain), for carrying out the randomization process in this study. The CIBEROBN is an initiative of the Instituto de Salud Carlos III, Madrid, Spain.
dc.description.versionSi
dc.identifier.citationGutierrez-Mariscal FM, García-Ríos A, Gómez-Luna P, Fernández-Gandara C, Cardelo MP, de la Cruz-Ares S, et al. Age-dependent effect of metabolic phenotypes on carotid atherosclerotic disease in coronary heart disease patients (CORDIOPREV study). BMC Geriatr. 2020 Apr 22;20(1):151.
dc.identifier.doi10.1186/s12877-020-01544-5
dc.identifier.essn1471-2318
dc.identifier.pmcPMC7178935
dc.identifier.pmid32321443
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178935/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1186/s12877-020-01544-5
dc.identifier.urihttp://hdl.handle.net/10668/15414
dc.issue.number1
dc.journal.titleBMC geriatrics
dc.journal.titleabbreviationBMC Geriatr
dc.language.isoen
dc.organizationIMIBIC
dc.page.number151
dc.publisherBioMed Central Ltd.
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.publisherversionhttps://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-020-01544-5
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCardiovascular risk factors
dc.subjectCarotid atherosclerosis
dc.subjectMetabolic flexibility
dc.subjectMetabolically healthy obese
dc.subject.decsAdulto
dc.subject.decsAnciano
dc.subject.decsArterias carótidas
dc.subject.decsEnfermedad coronaria
dc.subject.decsEnfermedades de las arterias carótidas
dc.subject.decsEspaña
dc.subject.decsEstudios transversales
dc.subject.decsFactores de edad
dc.subject.decsFactores de riesgo
dc.subject.decsFenotipo
dc.subject.decsGrosor intima-media carotídeo
dc.subject.decsObesidad abdominal
dc.subject.decsPlaca aterosclerótica
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshCarotid Arteries
dc.subject.meshCarotid Artery Diseases
dc.subject.meshCarotid Intima-Media Thickness
dc.subject.meshCoronary Disease
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshObesity, Abdominal
dc.subject.meshPhenotype
dc.subject.meshPlaque, Atherosclerotic
dc.subject.meshPrevalence
dc.subject.meshRisk Factors
dc.subject.meshSpain
dc.subject.meshTunica Intima
dc.subject.meshTunica Media
dc.subject.meshUltrasonography
dc.titleAge-dependent effect of metabolic phenotypes on carotid atherosclerotic disease in coronary heart disease patients (CORDIOPREV study).
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number20
dspace.entity.typePublication

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