Publication:
Risk factors for infection by oncogenic human papillomaviruses in HIV-positive MSM patients in the ART era (2010-2016).

dc.contributor.authorHidalgo-Tenorio, Carmen
dc.contributor.authorGil-Anguita, Concepción
dc.contributor.authorRamírez-Taboada, Jessica
dc.contributor.authorEsquivias, Javier
dc.contributor.authorLópez-Ruz, Miguel A
dc.contributor.authorBalgahata, Omar Mohamed
dc.contributor.authorJavier-Martinez, Rosario
dc.contributor.authorPasquau, Juan
dc.date.accessioned2023-01-25T10:00:38Z
dc.date.available2023-01-25T10:00:38Z
dc.date.issued2017
dc.description.abstractSquamous cell carcinoma of anus (SCCA) is one of the most frequent non-AIDS-defining diseases in HIV patients, mainly in men who have sex with men (MSM), and it is associated with human papillomavirus (HPV) infection.To determine the prevalence of high-risk HPV (HR-HPV) genotypes, premalignant lesions (HSIL) and SCCA in a cohort of HIV-positive MSM; to study the distribution of HPV genotypes according to anal histology results; and to analyze risk factors for this infection.This prospective single-center study was conducted between May 2010 and September 2016. At the study visit, cotton swabs were used to collect anal samples for cytology study in ThinPrep Pap Test liquid medium (Thin Prep Processor 2000, Hologic Corp, USA), and for HPV PCR (Linear Array HPV Genotyping Test). After, high-resolution anoscopy (HRA) (Zeiss 150 fc) was carried out. Logistic regression analysis was performed to identify risk factors for HR-HPV infection.The study included 319 patients, with mean age of 36.7 years; HR-HPV was detected in 81.3%. The prevalence of HSIL was 13.5% and SCCA was 0.3%. With regard to the distribution of HPV genotypes according to histology results, HPV 16 was the most frequent genotype in normal anal mucosa (26.7%), in LSILs (36.9%), and in HSILs (38%). In multivariate analysis, CD4 nadir 
dc.identifier.doi10.1097/MD.0000000000008109
dc.identifier.essn1536-5964
dc.identifier.pmcPMC5626276
dc.identifier.pmid28953633
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626276/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1097/md.0000000000008109
dc.identifier.urihttp://hdl.handle.net/10668/11618
dc.issue.number39
dc.journal.titleMedicine
dc.journal.titleabbreviationMedicine (Baltimore)
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario de Jaén
dc.page.numbere8109
dc.pubmedtypeJournal Article
dc.pubmedtypeObservational Study
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.meshAdult
dc.subject.meshAnal Canal
dc.subject.meshAnti-Retroviral Agents
dc.subject.meshAnus Neoplasms
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshEndoscopy, Gastrointestinal
dc.subject.meshGenotype
dc.subject.meshHIV Infections
dc.subject.meshHomosexuality, Male
dc.subject.meshHuman papillomavirus 16
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMultivariate Analysis
dc.subject.meshOncogenes
dc.subject.meshPapillomaviridae
dc.subject.meshPapillomavirus Infections
dc.subject.meshPrevalence
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.titleRisk factors for infection by oncogenic human papillomaviruses in HIV-positive MSM patients in the ART era (2010-2016).
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number96
dspace.entity.typePublication

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