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Circadian Genes as Therapeutic Targets in Pancreatic Cancer

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dc.contributor.authorGarcía-Costela, María
dc.contributor.authorEscudero-Feliú, Julia
dc.contributor.authorPuentes-Pardo, Jose D.
dc.contributor.authorSan Juán, Sara Moreno
dc.contributor.authorMorales-Santana, Sonia
dc.contributor.authorRíos-Arrabal, Sandra
dc.contributor.authorCarazo, Ángel
dc.contributor.authorLeón, Josefa
dc.contributor.authoraffiliation[García-Costela,M; Escudero-Feliú,J; Puentes-Pardo,JD; Ríos-Arrabal,S; León,J] Research Unit, Biosanitary Research Institute of Granada, ibs.GRANADA, Granada, Spain. [San Juán,SM] Cytometry and Michroscopy Research Service, Biosanitary Research Institute of Granada, ibs.GRANADA, Granada, Spain. [Morales-Santana,S] Proteomic Research Service, Biosanitary Research Institute of Granada, ibs.GRANADA, Granada, Spain. [Morales-Santana,S] Endocrinology Unit, Endocrinology Division, CIBER of Fragility and Healthy Aging (CIBERFES), San Cecilio University Hospital, Granada, Spain. [Carazo,A] Genomic Research Service, Biosanitary Research Institute of Granada, ibs.GRANADA, Granada, Spain. [León,J] Clinical Management Unit of Digestive Disease, San Cecilio University Hospital, Granada, Spain.
dc.contributor.funderJL was supported by the Nicolás Monardes Program from the Andalusian Health Service (C-0033-2015). This work was supported by a research grant from the Instituto de Salud Carlos III-FEDER (PI18/01947).
dc.date.accessioned2022-03-30T06:33:35Z
dc.date.available2022-03-30T06:33:35Z
dc.date.issued2020-09-11
dc.description.abstractPancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.es_ES
dc.description.versionYeses_ES
dc.identifier.citationGarcía-Costela M, Escudero-Feliú J, Puentes-Pardo JD, San Juán SM, Morales-Santana S, Ríos-Arrabal S, et al. Circadian Genes as Therapeutic Targets in Pancreatic Cancer. Front Endocrinol (Lausanne). 2020 Sep 11;11:638es_ES
dc.identifier.doi10.3389/fendo.2020.00638es_ES
dc.identifier.essn1664-2392
dc.identifier.pmcPMC7516350
dc.identifier.pmid33042011es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3502
dc.journal.titleFrontiers in Endocrinology
dc.language.isoen
dc.page.number17 p.
dc.publisherFrontierses_ES
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fendo.2020.00638/fulles_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPancreatic canceres_ES
dc.subjectCircadian clockes_ES
dc.subjectChemotherapyes_ES
dc.subjectMetabolismes_ES
dc.subjectPrecision medicinees_ES
dc.subjectNeoplasias pancreáticases_ES
dc.subjectRelojes circadianoses_ES
dc.subjectDrug therapyes_ES
dc.subjectMetabolismoes_ES
dc.subjectMedicina de precisiónes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosises_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferationes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Biological Clocks::Circadian Clockses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian Rhythmes_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progressiones_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pancreatic Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Chemotherapy, Adjuvantes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolismes_ES
dc.titleCircadian Genes as Therapeutic Targets in Pancreatic Canceres_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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