Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?

Verge González, Carmen; Lucena González, María Isabel; López-Torres, Enrique; Puche-García, María José; Fraga, Enrique; Romero-Gómez, Manuel; Andrade Bellido, Raúl Jesús

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Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?

dc.contributor.author	Verge González, Carmen
dc.contributor.author	Lucena González, María Isabel
dc.contributor.author	López-Torres, Enrique
dc.contributor.author	Puche-García, María José
dc.contributor.author	Fraga, Enrique
dc.contributor.author	Romero-Gómez, Manuel
dc.contributor.author	Andrade Bellido, Raúl Jesús
dc.contributor.authoraffiliation	[Verge González,C; Lucena González,MI; López-Torres,E; Puche-García,MJ] Clinical Pharmacology Service, Hospital Universitario Virgen de la Victoria, School of Medicine, Málaga, Spain. [Fraga,E] Gastroenterology Service, University Hospital Reina Sofia, Córdoba, Spain. [Romero-Gómez,M] Gastroenterology Service, University Hospital Virgen de Valme, Sevilla, Spain. [Andrade Bellido,RJ] Liver Unit, Department of Gastroenterology, Hospital Universitario Virgen de la Victoria, Málaga, Spain.	es
dc.date.accessioned	2013-03-11T11:15:12Z
dc.date.available	2013-03-11T11:15:12Z
dc.date.issued	2006-08-21
dc.description	Case Reports; Journal Article; Research Support, Non-U.S. Gov't;	es
dc.description.abstract	Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.	es
dc.description.version	Yes	es
dc.identifier.citation	Verge González C, Lucena González MI, López-Torres E, Puche-García MJ, Fraga E, Romero-Gómez M, et al. Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs? World J. Gastroenterol.. 2006;12(31):5078-80	es
dc.identifier.essn	2219-2840
dc.identifier.issn	1007-9327
dc.identifier.pmid	16937512
dc.identifier.uri	http://hdl.handle.net/10668/815
dc.journal.title	World Journal of Gastroenterology : WJG
dc.language.iso	en
dc.organization	AGS Sur de Sevilla
dc.publisher	Baishideng Publishing Group Co. Limited	es
dc.relation.publisherversion	http://www.wjgnet.com/1007-9327/full/v12/i31/5078.htm	es
dc.rights.accessRights	open access
dc.subject	Calcium carbimide	es
dc.subject	Hepatotoxicity	es
dc.subject	Disuasivos de Alcohol	es
dc.subject	Cianamida	es
dc.subject	Disulfiram	es
dc.subject	Interacciones de Drogas	es
dc.subject	Hígado	es
dc.subject	Enfermedad Hepática Inducida por Drogas	es
dc.subject	Femenino	es
dc.subject	Humanos	es
dc.subject	Masculino	es
dc.subject	Mediana Edad	es
dc.subject	Adulto	es
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Alcohol Deterrents	es
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Nitrogen Compounds::Hydrogen Cyanide::Cyanides::Cyanamide	es
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamates::Thiocarbamates::Ditiocarb::Disulfiram	es
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Pharmacological Processes::Drug Interactions	es
dc.subject.mesh	Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Drug-Induced Liver Injury	es
dc.subject.mesh	Medical Subject Headings::Check Tags::Female	es
dc.subject.mesh	Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans	es
dc.subject.mesh	Medical Subject Headings::Anatomy::Digestive System::Liver	es
dc.subject.mesh	Medical Subject Headings::Check Tags::Male	es
dc.subject.mesh	Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged	es
dc.subject.mesh	Medical Subject Headings::Named Groups::Persons::Age Groups::Adult	es
dc.title	Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?	es
dc.type	research article
dc.type.hasVersion	VoR
dspace.entity.type	Publication

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Publication: Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?

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Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy: is there still a role for these drugs?