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Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

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dc.contributor.authorvan den Heuvel-Eibrink, Marry M.
dc.contributor.authorHol, Janna A.
dc.contributor.authorPritchard-Jones, Kathy
dc.contributor.authorvan Tinteren, Harm
dc.contributor.authorFurtwangler, Rhoikos
dc.contributor.authorVerschuur, Arnauld C.
dc.contributor.authorVujanic, Gordan M.
dc.contributor.authorLeuschner, Ivo
dc.contributor.authorBrok, Jesper
dc.contributor.authorRube, Christian
dc.contributor.authorSmets, Anne M.
dc.contributor.authorJanssens, Geert O.
dc.contributor.authorGodzinski, Jan
dc.contributor.authorRamirez-Villar, Gema L.
dc.contributor.authorde Camargo, Beatriz
dc.contributor.authorSegers, Heidi
dc.contributor.authorCollini, Paola
dc.contributor.authorGessler, Manfred
dc.contributor.authorBergeron, Christophe
dc.contributor.authorSpreafico, Filippo
dc.contributor.authorGraf, Norbert
dc.contributor.authorInt Soc Paediat Oncology Renal Tu
dc.contributor.authoraffiliation[van den Heuvel-Eibrink, Marry M.] Princess Maxima Ctr Paediat Oncol, Dept Paediat Oncol, Lundlaan 6, NL-3584 EA Utrecht, Netherlands
dc.contributor.authoraffiliation[Hol, Janna A.] Princess Maxima Ctr Paediat Oncol, Dept Paediat Oncol, Lundlaan 6, NL-3584 EA Utrecht, Netherlands
dc.contributor.authoraffiliation[Janssens, Geert O.] Princess Maxima Ctr Paediat Oncol, Dept Paediat Oncol, Lundlaan 6, NL-3584 EA Utrecht, Netherlands
dc.contributor.authoraffiliation[Pritchard-Jones, Kathy] UCL, Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England
dc.contributor.authoraffiliation[Brok, Jesper] UCL, Great Ormond St Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England
dc.contributor.authoraffiliation[van Tinteren, Harm] Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
dc.contributor.authoraffiliation[Furtwangler, Rhoikos] Saarland Univ, Dept Paediat Oncol & Haematol, Kirrberger Str 100, D-66421 Homburg, Germany
dc.contributor.authoraffiliation[Graf, Norbert] Saarland Univ, Dept Paediat Oncol & Haematol, Kirrberger Str 100, D-66421 Homburg, Germany
dc.contributor.authoraffiliation[Verschuur, Arnauld C.] La Timone Childrens Hosp, Dept Paediat Oncol & Haematol, 264 Rue St Pierre, F-13385 Marseille, France
dc.contributor.authoraffiliation[Vujanic, Gordan M.] Cardiff Univ, Sch Med, Univ Hosp Wales, Dept Cellular Pathol, Heath Pk,Eastern Ave, Cardiff CF14 4XW, S Glam, Wales
dc.contributor.authoraffiliation[Leuschner, Ivo] Univ Hosp Kiel, Dept Paediat Pathol, Kiel Paediat Tumour Registry, Christian Albrechts Pl 4, D-24118 Kiel, Germany
dc.contributor.authoraffiliation[Rube, Christian] Univ Hosp Saarland, Dept Radiotherapy, Kirrberger Str 100, D-66421 Homburg, Germany
dc.contributor.authoraffiliation[Smets, Anne M.] Acad Med Ctr Amsterdam, Dept Radiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
dc.contributor.authoraffiliation[Janssens, Geert O.] Univ Med Ctr Utrecht, Dept Radiat Oncol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands
dc.contributor.authoraffiliation[Godzinski, Jan] Marciniak Hosp, Dept Paediat Surg, Fieldorfa 2, PL-54049 Wroclaw, Poland
dc.contributor.authoraffiliation[Godzinski, Jan] Med Univ, Dept Paediat Traumatol & Emergency Med, Wybrzeze Ludwika Pasteura 1, PL-50367 Wroclaw, Poland
dc.contributor.authoraffiliation[Ramirez-Villar, Gema L.] Hosp Univ Virgen del Rocio, Dept Paediat Oncol, Av Manuel Siurot S-N, Seville 41013, Spain
dc.contributor.authoraffiliation[de Camargo, Beatriz] Inst Nacl Canc INCA, Paediat Haematol Oncol Program, Praca Cruz Vermelha 23, BR-20230130 Rio De Janeiro, Brazil
dc.contributor.authoraffiliation[Segers, Heidi] Univ Hosp Leuven, Dept Paediat Oncol, Herestr 49, B-3000 Leuven, Belgium
dc.contributor.authoraffiliation[Collini, Paola] Fdn IRCCS Ist Nazl Tumori, Dept Diagnost Pathol & Lab Med, Via Giacomo Venezian 1, I-20133 Milan, Italy
dc.contributor.authoraffiliation[Spreafico, Filippo] Fdn IRCCS Ist Nazl Tumori, Dept Diagnost Pathol & Lab Med, Via Giacomo Venezian 1, I-20133 Milan, Italy
dc.contributor.authoraffiliation[Gessler, Manfred] Univ Wurzburg, Bioctr, Dev Biochem & Comprehens Canc Ctr Mainfranken, Josef Schneider Str 6, D-97080 Wurzburg, Germany
dc.contributor.authoraffiliation[Bergeron, Christophe] Ctr Leon Berard, Inst Hematol & Oncol Pediat, 28 Prom, F-69008 Lyon, France
dc.date.accessioned2023-02-12T02:21:13Z
dc.date.available2023-02-12T02:21:13Z
dc.date.issued2017-12-01
dc.description.abstractThe Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.
dc.identifier.doi10.1038/nrurol.2017.163
dc.identifier.essn1759-4820
dc.identifier.issn1759-4812
dc.identifier.unpaywallURLhttps://www.nature.com/articles/nrurol.2017.163.pdf
dc.identifier.urihttp://hdl.handle.net/10668/18902
dc.identifier.wosID416609000012
dc.issue.number12
dc.journal.titleNature reviews urology
dc.journal.titleabbreviationNat. rev. urol.
dc.language.isoen
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number743-752
dc.publisherNature publishing group
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRandomized controlled-trial
dc.subjectPreoperative chemotherapy
dc.subjectStage-ii
dc.subjectInternational-society
dc.subjectPulmonary metastases
dc.subjectFavorable histology
dc.subjectIntermediate-risk
dc.subjectInitial treatment
dc.subjectActinomycin-d
dc.subjectRenal tumors
dc.titleRationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number14
dc.wostypeArticle
dspace.entity.typePublication

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