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Supraclavicular skin temperature measured by iButtons and 18F-fluorodeoxyglucose uptake by brown adipose tissue in adults.

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Date

2019-04-13

Authors

Martinez-Tellez, Borja
Garcia-Rivero, Yolanda
Sanchez-Delgado, Guillermo
Xu, Huiwen
Amaro-Gahete, Francisco J
Acosta, Francisco M
Rensen, Patrick C N
Boon, Mariëtte R
Llamas-Elvira, Jose M
Ruiz, Jonatan R

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Elsevier Ltd
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Abstract

Currently, 18 [F]-Fluorodeoxyglucose (18F-FDG) in combination with a positron emission tomography/computed tomography (PET/CT) scan analysis is the most commonly used method to quantify human BAT volume and activity. However, this technique presents several drawbacks which negatively affect participant's health. The aim of the present work is to determine whether supraclavicular skin temperature can be used as an indirect marker of cold-induced BAT and skeletal muscle 18F-FDG uptake in adults, while taking into account body composition. We performed a personalized cooling protocol just before an 18F-FDG-PET/CT scan, and we measured supraclavicular skin temperature before (in warm conditions) and after the cooling protocol in 88 adults (n = 57 women, mean age: 21.9 ± 2.1 years old, body mass index: 24.5 ± 4.3 km/m2). We found that supraclavicular skin temperature at the warm and cold periods was weakly and positively associated with BAT activity (SUVmean and SUVpeak: β = 3.000; R2 = 0.072; P = 0.022 and β = 2.448; R2 = 0.060; P = 0.021), but not with skeletal muscle 18F-FDG uptake, after controlling for body composition. We performed further analyses and the positive associations persisted only in the group of women. In conclusion, supraclavicular skin temperature in warm and cold conditions seems to be related with cold-induced 18F-FDG uptake by BAT only in women, although the low explained variance of these associations means that there are other factors involved in the supraclavicular skin temperature.

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MeSH Terms

Adipose Tissue, Brown
Adult
Body Composition
Cold Temperature
Female
Fluorodeoxyglucose F18
Humans
Male
Muscle, Skeletal
Positron Emission Tomography Computed Tomography
Skin Temperature
Young Adult

DeCS Terms

Composición corporal
Fluorodesoxiglucosa F18
Frío
Músculo esquelético
Tejido adiposo pardo
Temperatura cutánea
Tomografía computarizada por tomografía de emisión de positrones
Adulto
Femenino
Humanos
Masculino

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Keywords

Data-logger, Temperatus, brown fat, ibutton

Citation

Martinez-Tellez B, Garcia-Rivero Y, Sanchez-Delgado G, Xu H, Amaro-Gahete FJ, Acosta FM, et al. Supraclavicular skin temperature measured by iButtons and 18F-fluorodeoxyglucose uptake by brown adipose tissue in adults. J Therm Biol. 2019 May;82:178-185.