Publication: Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice.
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Identifiers
Date
2022-07-26
Authors
Roa, Juan
Ruiz-Cruz, Miguel
Ruiz-Pino, Francisco
Onieva, Rocio
Vazquez, Maria J
Sanchez-Tapia, Maria J
Ruiz-Rodriguez, Jose M
Sobrino, Veronica
Barroso, Alexia
Heras, Violeta
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Kiss1 neurons, producing kisspeptins, are essential for puberty and fertility, but their molecular regulatory mechanisms remain unfolded. Here, we report that congenital ablation of the microRNA-synthesizing enzyme, Dicer, in Kiss1 cells, causes late-onset hypogonadotropic hypogonadism in both sexes, but is compatible with pubertal initiation and preserved Kiss1 neuronal populations at the infantile/juvenile period. Yet, failure to complete puberty and attain fertility is observed only in females. Kiss1-specific ablation of Dicer evokes disparate changes of Kiss1-cell numbers and Kiss1/kisspeptin expression between hypothalamic subpopulations during the pubertal-transition, with a predominant decline in arcuate-nucleus Kiss1 levels, linked to enhanced expression of its repressors, Mkrn3, Cbx7 and Eap1. Our data unveil that miRNA-biosynthesis in Kiss1 neurons is essential for pubertal completion and fertility, especially in females, but dispensable for initial reproductive maturation and neuronal survival in both sexes. Our results disclose a predominant miRNA-mediated inhibitory program of repressive signals that is key for precise regulation of Kiss1 expression and, thereby, reproductive function.
Description
MeSH Terms
Animals
Female
Male
Mice
Neurons
Ribonuclease III
Sexual maturation
Female
Male
Mice
Neurons
Ribonuclease III
Sexual maturation
DeCS Terms
Maduración sexual
Masculino
Neuronas
Ratones
Ribonucleasa III
Masculino
Neuronas
Ratones
Ribonucleasa III
CIE Terms
Keywords
DEAD-box RNA helicases, Fertility, Kisspeptins, MicroRNAs
Citation
Roa J, Ruiz-Cruz M, Ruiz-Pino F, Onieva R, Vazquez MJ, Sanchez-Tapia MJ, et al. Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice. Nat Commun. 2022 Aug 9;13(1):4663