Publication: Bengamide Analogues Show A Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study.
Loading...
Identifiers
Date
2020-05-02
Authors
Garcia-Pinel, Beatriz
Porras-Alcala, Cristina
Cabeza, Laura
Ortiz, Raul
Prados, Jose
Melguizo, Consolacion
Cheng-Sanchez, Ivan
Lopez-Romero, Juan Manuel
Sarabia, Francisco
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract
The limited success and side effects of the current chemotherapeutic strategies against colorectal cancer (CRC), the third most common cancer worldwide, demand an assay with new drugs. The prominent antitumor activities displayed by the bengamides (Ben), a family of natural products isolated from marine sponges of the Jaspidae family, were explored and investigated as a new option to improve CRC treatment. To this end, two potent bengamide analogues, Ben I (5) and Ben V (10), were selected for this study, for which they were synthesized according to a new synthetic strategy recently developed in our laboratories. Their antitumor effects were analyzed in human and mouse colon cell lines, using cell cycle analysis and antiproliferative assays. In addition, the toxicity of the selected analogues was tested in human blood cells. These biological studies revealed that Ben I and V produced a significant decrease in CRC cell proliferation and induced a significant cell cycle alteration with a greater antiproliferative effect on tumor cell lines than normal cells. Interestingly, no toxicity effects were detected in blood cells for both compounds. All these biological results render the bengamide analogues Ben I and Ben V as promising antitumoral agents for the treatment of CRC.
Description
MeSH Terms
Animals
Antineoplastic Agents
Azepines
Cell Line, Tumor
Colonic Neoplasms
Drug Screening Assays, Antitumor
Humans
Porifera
Structure-Activity Relationship
Antineoplastic Agents
Azepines
Cell Line, Tumor
Colonic Neoplasms
Drug Screening Assays, Antitumor
Humans
Porifera
Structure-Activity Relationship
DeCS Terms
Productos biológicos
Ciclo celular
Terapéutica
Células sanguíneas
Neoplasias colorrectales
Estrategias de salud
Laboratorios
Células
Línea celular
Neoplasias
Colon
Ciclo celular
Terapéutica
Células sanguíneas
Neoplasias colorrectales
Estrategias de salud
Laboratorios
Células
Línea celular
Neoplasias
Colon
CIE Terms
Keywords
analogues, antitumor agents, bengamides, colorectal cancer, synthesis
Citation
García-Pinel B, Porras-Alcalá C, Cabeza L, Ortiz R, Prados J, Melguizo C, et al. Bengamide Analogues Show A Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study. Mar Drugs. 2020 May 2;18(5):240.