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Challenges and achievements of liquid biopsy technologies employed in early breast cancer

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dc.contributor.authorAlba-Bernal, Alfonso
dc.contributor.authorLavado-Valenzuela, Rocío
dc.contributor.authorDomínguez-Recio, María Emilia
dc.contributor.authorJiménez-Rodriguez, Begoña
dc.contributor.authorQueipo-Ortuño, María Isabel
dc.contributor.authorAlba, Emilio
dc.contributor.authorComino-Méndez, Iñaki
dc.contributor.authoraffiliation[Alba-Bernal,A; Lavado-Valenzuela,R; Domínguez-Recio,ME; Jiménez-Rodriguez,B; Queipo-Ortuño,MI; Alba,E; Comino-Méndez,I] Unidad de Gestion Clínica Intercentros de Oncología Medica, Hospitales Universitarios Regional y Virgen de la Victoria. The Biomedical Research Institute of Málaga (IBIMA-CIMES-UMA), Málaga, Spain.
dc.contributor.funderICM's contract is funded by the Spanish Association Against Cancer (AECC). AAB is contracted by the “Garantía Juvenil en I+D+i Subprograma Estatal de Incorporacion” by the Ministry of Science and Innovation (Spanish Government). MIQO contract is supported by the “Miguel Servet Type II” program (CPI13/00003), ISCIII, Spain and cofunded by the "Fondo Europeo de Desarrollo Regional-(FEDER)", and by the “Nicolas Monardes” research program from the "Consejería de Salud" (C-0030-2018), Andalusian Gobernment, Spain.
dc.date.accessioned2022-07-08T11:30:19Z
dc.date.available2022-07-08T11:30:19Z
dc.date.issued2020-11-09
dc.description.abstractBreast cancer is the most common cancer type in women worldwide and its early detection is crucial to curing the disease. Tissue biopsy, currently the method of choice to obtain tumour molecular information, is invasive and might be affected by tumour heterogeneity rendering it incapable to portray the complete molecular picture. Liquid biopsy permits to study disease features in a more comprehensive manner by sampling biofluids and extracting tumour components such as circulating-tumour DNA (ctDNA), circulating-tumour cells (CTCs), and/or circulating-tumour RNA (ctRNA) amongst others in a monitoring-compatible manner. In this review, we describe the recent progress in the utilization of the circulating tumour components using early breast cancer samples. We review the most important analytes and technologies employed for their study.es_ES
dc.description.versionYeses_ES
dc.identifier.citationAlba-Bernal A, Lavado-Valenzuela R, Domínguez-Recio ME, Jiménez-Rodriguez B, Queipo-Ortuño MI, Alba E, et al. Challenges and achievements of liquid biopsy technologies employed in early breast cancer. EBioMedicine. 2020 Dec;62:103100es_ES
dc.identifier.doi10.1016/j.ebiom.2020.103100es_ES
dc.identifier.essn2352-3964
dc.identifier.pmcPMC7670097
dc.identifier.pmid33161226es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3766
dc.journal.titleEBioMedicine
dc.language.isoen
dc.page.number10 p.
dc.publisherElsevieres_ES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S235239642030476X?via%3Dihubes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLiquid biopsyes_ES
dc.subjectLocalized breast canceres_ES
dc.subjectCirculating-tumour DNAes_ES
dc.subjectCirculating-tumour cellses_ES
dc.subjectCirculating-tumour RNAes_ES
dc.subjectBiopsia líquidaes_ES
dc.subjectNeoplasias de la mamaes_ES
dc.subjectARNes_ES
dc.subjectADNes_ES
dc.subjectCélulases_ES
dc.subjectARN Circulares_ES
dc.subjectPacienteses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Neoplasmes_ES
dc.subject.meshMedical Subject Headings::Health Care::Health Services Administration::Patient Care Management::Disease Managementes_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibilityes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Early Diagnosis::Early Detection of Canceres_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsyes_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis::Neoplastic Cells, Circulatinges_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Antisense::MicroRNAses_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Patientses_ES
dc.titleChallenges and achievements of liquid biopsy technologies employed in early breast canceres_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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