Publication: HIV infection and multiple sclerosis: a case with unexpected "no evidence of disease activity" status
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Identifiers
Date
2021-03-25
Authors
Labella, Fernando
Acebrón, Fernando
Blanco-Valero, María del Carmen
Rodrígez-Martín, Alba
Monterde Ortega, Ángela
Agüera Morales, Eduardo
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Publisher
Sage Publications Ltd.
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Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system whose etiology remains unclear. It has been suggested that MS can be triggered by certain viruses; however, human immunodeficiency virus (HIV) infection is associated with reduced incidence of MS. We present the case of a young patient diagnosed with active relapsing-remitting MS whose clinical course substantially improved following HIV infection and treatment. The patient achieved no evidence of disease activity status without any disease-modifying drugs. Both HIV-induced immunosuppression and antiretroviral therapy may have attenuated the clinical course in this patient.
Description
MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Medical Subject Headings::Organisms::Viruses
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression
Medical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
Multiple Sclerosis, Relapsing-Remitting
Medical Subject Headings::Organisms::Viruses
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression
DeCS Terms
CIE Terms
Keywords
Multiple sclerosis, Human immunodeficiency virus, Human endogenous retrovirus, Highly active antiretroviral therapy, Immunosuppression, No evidence of disease activity, Epstein–Barr virus, Esclerosis múltiple, VIH, Retrovirus endógenos, Terapia antirretroviral altamente activa, Terapia de inmunosupresión, Herpesvirus humano 4
Citation
Labella F, Acebrón F, Blanco-Valero MDC, Rodrígez-Martín A, Monterde Ortega Á, Agüera Morales E. HIV infection and multiple sclerosis: a case with unexpected "no evidence of disease activity" status. J Int Med Res. 2021 Mar;49(3):300060521999577.