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Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer.

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dc.contributor.authorMinicozzi, Pamela
dc.contributor.authorVan Eycken, Liesbet
dc.contributor.authorMolinie, Florence
dc.contributor.authorInnos, Kaire
dc.contributor.authorGuevara, Marcela
dc.contributor.authorMarcos-Gragera, Rafael
dc.contributor.authorCastro, Clara
dc.contributor.authorRapiti, Elisabetta
dc.contributor.authorKatalinic, Alexander
dc.contributor.authorTorrella, Ana
dc.contributor.authorŽagar, Tina
dc.contributor.authorBielska-Lasota, Magdalena
dc.contributor.authorGiorgi Rossi, Paolo
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorBastos, Joana
dc.contributor.authorSanchez-Perez, Maria-Jose
dc.contributor.authorSant, Milena
dc.contributor.funderAndalusian Department of Health.
dc.contributor.funderSpanish National Institute of Health, Carlos III
dc.contributor.funderLa Caixa Foundation
dc.contributor.funderMinistry of Education, Science and Sport (MIZS), Slovenia
dc.contributor.funderNaradowe Centrum Badań i Rozwoju, Poland
dc.contributor.funderFederal Ministry of Education and Research (BMBF), Germany
dc.contributor.funderInstitut National du Cancer, France
dc.contributor.funderResearch Foundation Flanders (FWO), Belgium
dc.contributor.funderMinistry of Health, Italy
dc.contributor.groupEuropean HR Working Group on breast cancer
dc.date.accessioned2023-01-25T10:24:11Z
dc.date.available2023-01-25T10:24:11Z
dc.date.issued2018-10-23
dc.description.abstractSurvival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 stage I/IIA cases diagnosed in 9 European countries in 2009-2013, and 4 STs: surgery; breast-conserving surgery plus radiotherapy (BCS + RT); reconstruction after mastectomy; and prompt treatment (≤6 weeks after diagnosis). Covariate-adjusted models estimated odds of receiving STs and risks of death/relapse, according to comorbidities. Pearson's R assessed correlations between odds and risks. The z-test assessed the significance of time-trends. Most women received surgery: 72% BCS; 24% mastectomy. Mastectomied patients were older with more comorbidities than BCS patients (p
dc.description.sponsorshipThe authors thank Don Ward for help with the English, and the participating cancer registries for collecting and preparing the data as part of their essential role in cancer control. This work was carried out as part of HIGHCARE (High resolution project on prognosis and care of cancer patients); it was supported in part by ERA-NET within the framework of the call on “Translational research on tertiary prevention in cancer patients” (TRANSCAN) with funding from: Ministry of Health, Italy; Research Foundation Flanders (FWO), Belgium; Institut National du Cancer, France; Federal Ministry of Education and Research (BMBF), Germany; Naradowe Centrum Badań i Rozwoju, Poland; Ministry of Education, Science and Sport (MIZS), Slovenia; and Instituto de Salud Carlos III, Spain. La Caixa Foundation partially supported the Navarra CR for this study. The Spanish National Institute of Health, Carlos III [grant number AC14/00036], and the Andalusian Department of Health [grant number PI-0152/2017] partially supported the Granada CR for this study.
dc.description.versionSi
dc.identifier.citationMinicozzi P, Van Eycken L, Molinie F, Innos K, Guevara M, Marcos-Gragera R, et al. Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer. Int J Cancer. 2019 May 1;144(9):2118-2127.
dc.identifier.doi10.1002/ijc.31974
dc.identifier.essn1097-0215
dc.identifier.pmid30411340
dc.identifier.unpaywallURLhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31974
dc.identifier.urihttp://hdl.handle.net/10668/13164
dc.issue.number9
dc.journal.titleInternational journal of cancer
dc.journal.titleabbreviationInt J Cancer
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number2118-2127
dc.provenanceRealizada la curación de contenido 30/07/2024
dc.publisherJohn Wiley & Sons, Inc.
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDPI-0152/2017
dc.relation.projectIDAC14/00036
dc.relation.publisherversionhttps://doi.org/10.1002/ijc.31974
dc.rights.accessRightsRestricted Access
dc.subjectcomorbidities
dc.subjectearly breast cancer
dc.subjectoutcomes
dc.subjectpopulation study
dc.subjectstandard treatment
dc.subject.decsAdolescente
dc.subject.decsAdulto
dc.subject.decsAnciano
dc.subject.decsComorbilidad
dc.subject.decsFactores de edad
dc.subject.decsMamoplastia
dc.subject.decsMastectomía segmentaria
dc.subject.decsNeoplasias de la mama
dc.subject.decsRadioterapia adyuvante
dc.subject.decsResultado del tratamiento
dc.subject.decsTerapia combinada
dc.subject.decsTiempo de tratamiento
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshBreast Neoplasms
dc.subject.meshCombined Modality Therapy
dc.subject.meshComorbidity
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMammaplasty
dc.subject.meshMastectomy, Segmental
dc.subject.meshMiddle Aged
dc.subject.meshRadiotherapy, Adjuvant
dc.subject.meshTime-to-Treatment
dc.subject.meshTreatment Outcome
dc.subject.meshYoung Adult
dc.titleComorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number144
dspace.entity.typePublication

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