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Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort.

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dc.contributor.authorvan Roekel, Eline H
dc.contributor.authorTrijsburg, Laura
dc.contributor.authorAssi, Nada
dc.contributor.authorCarayol, Marion
dc.contributor.authorAchaintre, David
dc.contributor.authorMurphy, Neil
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorSchmidt, Julie A
dc.contributor.authorStepien, Magdalena
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorIqbal, Khalid
dc.contributor.authorPalli, Domenico
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorArdanaz, Eva
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorHuerta, José M
dc.contributor.authorMolina-Portillo, Elena
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorRiboli, Elio
dc.contributor.authorRostgaard-Hansen, Agnetha Linn
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorHåkansson, Anders
dc.contributor.authorMalm, Johan
dc.contributor.authorWeijenberg, Matty P
dc.contributor.authorGunter, Marc J
dc.contributor.authorJenab, Mazda
dc.contributor.authorJohansson, Mattias
dc.contributor.authorTravis, Ruth C
dc.contributor.authorScalbert, Augustin
dc.contributor.authorFerrari, Pietro
dc.date.accessioned2023-01-25T10:09:37Z
dc.date.available2023-01-25T10:09:37Z
dc.date.issued2018-05-22
dc.description.abstractIdentifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value
dc.identifier.doi10.3390/nu10050654
dc.identifier.essn2072-6643
dc.identifier.pmcPMC5986533
dc.identifier.pmid29789452
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986533/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6643/10/5/654/pdf?version=1527068884
dc.identifier.urihttp://hdl.handle.net/10668/12500
dc.issue.number5
dc.journal.titleNutrients
dc.journal.titleabbreviationNutrients
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationHospital Universitario San Cecilio
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectacylcarnitines
dc.subjectalcohol
dc.subjectamino acids
dc.subjectlipid metabolites
dc.subjecttargeted metabolomics
dc.subject.meshAged
dc.subject.meshAlcohol Drinking
dc.subject.meshBiomarkers
dc.subject.meshBiotransformation
dc.subject.meshChromatography, High Pressure Liquid
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLife Style
dc.subject.meshLipids
dc.subject.meshMale
dc.subject.meshMetabolomics
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasms
dc.subject.meshNutritional Status
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.subject.meshSelf Report
dc.subject.meshSex Factors
dc.subject.meshSmoking
dc.subject.meshTandem Mass Spectrometry
dc.titleCirculating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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