Publication: Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort.
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Date
2018-05-22
Authors
van Roekel, Eline H
Trijsburg, Laura
Assi, Nada
Carayol, Marion
Achaintre, David
Murphy, Neil
Rinaldi, Sabina
Schmidt, Julie A
Stepien, Magdalena
Kaaks, Rudolf
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Abstract
Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value
Description
MeSH Terms
Aged
Alcohol Drinking
Biomarkers
Biotransformation
Chromatography, High Pressure Liquid
Europe
Female
Humans
Life Style
Lipids
Male
Metabolomics
Middle Aged
Neoplasms
Nutritional Status
Prospective Studies
Risk Factors
Self Report
Sex Factors
Smoking
Tandem Mass Spectrometry
Alcohol Drinking
Biomarkers
Biotransformation
Chromatography, High Pressure Liquid
Europe
Female
Humans
Life Style
Lipids
Male
Metabolomics
Middle Aged
Neoplasms
Nutritional Status
Prospective Studies
Risk Factors
Self Report
Sex Factors
Smoking
Tandem Mass Spectrometry
DeCS Terms
CIE Terms
Keywords
acylcarnitines, alcohol, amino acids, lipid metabolites, targeted metabolomics