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Acute oxygen sensing in heme oxygenase-2 null mice.

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dc.contributor.authorOrtega-Sáenz, Patricia
dc.contributor.authorPascual, Alberto
dc.contributor.authorGómez-Díaz, Raquel
dc.contributor.authorLópez-Barneo, José
dc.contributor.authoraffiliationLaboratorio de Investigaciones Biomédicas, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla,Spaines
dc.contributor.funderResearch was supported by the Spanish Ministry of Health, the Lilly Foundation, and the Andalusian Government.
dc.date.accessioned2014-09-02T09:29:19Z
dc.date.available2014-09-02T09:29:19Z
dc.date.issued2006-10
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;. A Pascual is an investigator of the “Ramón y Cajal” program. J. López-Barneo received the “Ayuda a la Investigación 2000” of the Juan March Foundationes
dc.description.abstractHemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K(+) channels and has been proposed to be the acute O(2) sensor in the carotid body (CB). We have tested the physiological contribution of this enzyme to O(2) sensing using HO-2 null mice. HO-2 deficiency leads to a CB phenotype characterized by organ growth and alteration in the expression of stress-dependent genes, including the maxi-K(+) channel alpha-subunit. However, sensitivity to hypoxia of CB is remarkably similar in HO-2 null animals and their control littermates. Moreover, the response to hypoxia in mouse and rat CB cells was maintained after blockade of maxi-K(+) channels with iberiotoxin. Hypoxia responsiveness of the adrenal medulla (AM) (another acutely responding O(2)-sensitive organ) was also unaltered by HO-2 deficiency. Our data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K(+) channel gene expression but it does not alter the intrinsic O(2) sensitivity of CB or AM cells. Therefore, HO-2 is not a universally used acute O(2) sensor.es
dc.description.versionYeses
dc.identifier.citationOrtega-Sáenz P, Pascual A, Gómez-Díaz R, López-Barneo J. Acute oxygen sensing in heme oxygenase-2 null mice. J Gen Physiol. 2006; 128(4):405-1es
dc.identifier.doi10.1085/jgp.200609591
dc.identifier.essn1540-7748
dc.identifier.issn0022-1295
dc.identifier.pmcPMC2151578
dc.identifier.pmid16966473
dc.identifier.urihttp://hdl.handle.net/10668/1703
dc.journal.titleThe Journal of General Physiology
dc.language.isoen
dc.publisherRockefeller University Presses
dc.relation.publisherversionhttp://jgp.rupress.org/content/128/4/405.long#abstract-1es
dc.rights.accessRightsopen access
dc.subjectAnimaleses
dc.subjectAnimales Recién Nacidoses
dc.subjectCalcioes
dc.subjectCuerpo Carotídeoes
dc.subjectCatecolaminases
dc.subjectCélulas Cromafineses
dc.subjectCiclofilinases
dc.subjectExpresión Génicaes
dc.subjectHemo Oxigenasa (Deciclizadora)es
dc.subjectHemo-Oxigenasa 1es
dc.subjectSubunidades alfa de los Canales de Potasio de Gran Conductancia Activados por Calcioes
dc.subjectCanales de Potasio de Gran Conductancia Activados por el Calcioes
dc.subjectRatoneses
dc.subjectRatones Consanguíneos C57BLes
dc.subjectRatones Noqueadoses
dc.subjectTamaño de los Órganoses
dc.subjectOxígenoes
dc.subjectPresión Parciales
dc.subjectTécnicas de Placa-Clampes
dc.subjectPéptidoses
dc.subjectBloqueadores de los Canales de Potasioes
dc.subjectRatases
dc.subjectMédula Suprarrenales
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Newbornes
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Respiratory::Anoxiaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Alkaline Earth::Calciumes
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Neurons::Neurons, Afferent::Sensory Receptor Cells::Chemoreceptor Cells::Paraganglia, Nonchromaffin::Carotid Bodyes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamineses
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Chromaffin Cellses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::cis-trans-Isomerases::Peptidylprolyl Isomerase::Immunophilins::Cyclophilinses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expressiones
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)es
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1es
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels::Potassium Channels, Calcium-Activated::Large-Conductance Calcium-Activated Potassium Channelses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Micees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BLes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic::Mice, Knockoutes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Organ Sizees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Chalcogens::Oxygenes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Pressure::Partial Pressurees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Cytological Techniques::Patch-Clamp Techniqueses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptideses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Membrane Transport Modulators::Potassium Channel Blockerses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Ratses
dc.subject.meshTyrosine 3-Monooxygenasees
dc.subject.meshMedical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Adrenal Glands::Adrenal Medullaes
dc.titleAcute oxygen sensing in heme oxygenase-2 null mice.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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