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Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma

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dc.contributor.authorPérez-Ruiz, Elisabeth
dc.contributor.authorGutiérrez, Vanesa
dc.contributor.authorMuñoz, Marta
dc.contributor.authorOliver, Javier
dc.contributor.authorSánchez, Marta
dc.contributor.authorGálvez-Carvajal, Laura
dc.contributor.authorRueda-Domínguez, Antonio
dc.contributor.authorBarragán, Isabel
dc.contributor.authoraffiliation[Pérez-Ruiz,E; Gutiérrez,V; Muñoz,M; Gálvez-Carvajal,L; Rueda-Domínguez,A] Unidad de Gestión Clínica Intercentros de Oncología Médica, Oncology Department, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Oliver,J; Barragán,I] Researcher Unit, Unidad de Gestión Clínica Intercentros de Oncología Médica, Institute of Biomedical Investigation of Malaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Malaga, Spain. [Sánchez,M] Maxillofacial Surgery Department, Hospital Regional Universitario de Málaga, Málaga, Spain. [Barragán,I] Group of Pharmacoepigenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
dc.contributor.funderE.P.-R. has received a grant from The Spanish Society of Medical Oncology (SEOM). IB has received funding (project SA 0263/2017, Nicolás Monardes Program) from the Consejería de Salud y Familias, Junta de Andalucía, Spain.
dc.date.accessioned2022-11-07T07:57:19Z
dc.date.available2022-11-07T07:57:19Z
dc.date.issued2021-10-15
dc.description.abstractOral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.es_ES
dc.description.versionYeses_ES
dc.identifier.citationPérez-Ruiz E, Gutiérrez V, Muñoz M, Oliver J, Sánchez M, Gálvez-Carvajal L, et al. Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma. Biomedicines. 2021 Oct 15;9(10):1478es_ES
dc.identifier.doi10.3390/biomedicines9101478es_ES
dc.identifier.essn2227-9059
dc.identifier.pmcPMC8533108
dc.identifier.pmid34680596es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4333
dc.journal.titleBiomedicines
dc.language.isoen
dc.page.number12 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/9/10/1478/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOral cell carcinomaes_ES
dc.subjectField cancerizationes_ES
dc.subjectLiquid biopsyes_ES
dc.subjectTobaccoes_ES
dc.subjectSalivaes_ES
dc.subjectEarly diagnosises_ES
dc.subjectCarcinoma de células escamosas de cabeza y cuelloes_ES
dc.subjectBiopsia líquidaes_ES
dc.subjectTabacoes_ES
dc.subjectDiagnóstico precozes_ES
dc.subjectDetección precoz del cánceres_ES
dc.subject.meshMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Mouth Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Carcinoma, Squamous Celles_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Solanaceae::Tobaccoes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Fluids and Secretions::Bodily Secretions::Salivaes_ES
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation::Goalses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms, Second Primaryes_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Ratees_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factorses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Early Diagnosises_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsyes_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrencees_ES
dc.titleLiquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinomaes_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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