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Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.

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dc.contributor.authorMerchan-Ramirez, Elisa
dc.contributor.authorSanchez-Delgado, Guillermo
dc.contributor.authorArrizabalaga-Arriazu, Cristina
dc.contributor.authorAcosta, Francisco M
dc.contributor.authorArias-Tellez, Maria Jose
dc.contributor.authorMuñoz-Torres, Manuel
dc.contributor.authorGarcia-Lario, Jose V
dc.contributor.authorLlamas-Elvira, Jose M
dc.contributor.authorRuiz, Jonatan R
dc.contributor.funderUniversidad de Granada / CBUA
dc.contributor.funderSpanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III
dc.contributor.funderEuropean Regional Development Funds (ERDF)
dc.contributor.funderSpanish Ministry of Education
dc.contributor.funderUniversity of Granada
dc.contributor.funderFundación Alfonso Martín Escudero
dc.date.accessioned2023-05-03T14:09:09Z
dc.date.available2023-05-03T14:09:09Z
dc.date.issued2022-04-06
dc.description.abstractThyroid dysfunction is associated with classic cardiometabolic risk factors in humans. However, this relationship remains unclear in young euthyroid adults. The present work examines the associations of circulating thyroid hormones (THs) and thyroid-stimulating hormone (TSH) concentrations with body composition and cardiometabolic risk factors in young euthyroid adults. A total of 106 sedentary, euthyroid adults (72 women; 22 ± 2 years old) participated in this cross-sectional study. THs and TSH serum concentrations were determined in fasting conditions (6 h). Body composition (fat mass (FM), lean mass (LM), and visceral adipose tissue (VAT)) was determined by dual-energy X-ray absorptiometry, anthropometric parameters (weight, height, and waist circumference) were measured, and neck adipose tissue mass was quantified through computed tomography (CT) scanning. Cardiometabolic risk factors including fasting glucose and lipid metabolism markers, hepatic phosphatase and transaminases, and blood pressure were also assessed. Free triiodothyronine (FT3) concentration was positively associated with body mass index, LM, VAT, and waist circumference (all P ≤ 0.038). FT3 was also associated with glucose, insulin, HOMA-IR, fatty liver index, and blood pressure (all P 
dc.description.versionSi
dc.identifier.citationMerchan-Ramirez E, Sanchez-Delgado G, Arrizabalaga-Arriazu C, Acosta FM, Arias-Tellez MJ, Muñoz-Torres M, et al. Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults. J Physiol Biochem. 2022 Aug;78(3):629-640.
dc.identifier.doi10.1007/s13105-022-00881-w
dc.identifier.essn1877-8755
dc.identifier.pmcPMC9381449
dc.identifier.pmid35381950
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381449/pdf
dc.identifier.unpaywallURLhttps://link.springer.com/content/pdf/10.1007/s13105-022-00881-w.pdf
dc.identifier.urihttp://hdl.handle.net/10668/21330
dc.issue.number3
dc.journal.titleJournal of physiology and biochemistry
dc.journal.titleabbreviationJ Physiol Biochem
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number629-640
dc.publisherSpringer Dordrecht
dc.pubmedtypeClinical Study
dc.pubmedtypeJournal Article
dc.relation.projectIDPI13/01393
dc.relation.projectIDFPU13/04365
dc.relation.projectIDRed SAMID RD16/0022
dc.relation.projectIDOMM17/6107/UGR
dc.relation.publisherversionhttps://dx.doi.org/10.1007/s13105-022-00881-w
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBody composition
dc.subjectCardiometabolic risk factors
dc.subjectEuthyroid
dc.subjectObesity
dc.subjectThyroid function
dc.subject.decsAdiposidad
dc.subject.decsCardiometabólico
dc.subject.decsFemenino
dc.subject.decsGlucosa
dc.subject.decsHormonas tiroideas
dc.subject.decsHumanos
dc.subject.decsHígado graso
dc.subject.decsObesidad
dc.subject.decsObesidad abdominal
dc.subject.decsTirotropina
dc.subject.decsTiroxina
dc.subject.decsTriyodotironina
dc.subject.decsÍndice de masa corporal
dc.subject.meshAdiposity
dc.subject.meshBody Mass Index
dc.subject.meshCardiometabolic Risk Factors
dc.subject.meshCross-Sectional Studies
dc.subject.meshFatty Liver
dc.subject.meshFemale
dc.subject.meshGlucose
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshObesity
dc.subject.meshObesity, Abdominal
dc.subject.meshRisk Factors
dc.subject.meshThyroid Hormones
dc.subject.meshThyrotropin
dc.subject.meshThyroxine
dc.subject.meshTriiodothyronine
dc.subject.meshYoung Adult
dc.titleCirculating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number78
dspace.entity.typePublication

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