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Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia

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dc.contributor.authorIllescas-Montes, Rebeca
dc.contributor.authorCostela-Ruiz, Víctor J.
dc.contributor.authorMelguizo-Rodríguez, Lucía
dc.contributor.authorDe Luna-Bertos, Elvira
dc.contributor.authorRuiz, Concepción
dc.contributor.authorRamos-Torrecillas, Javier
dc.contributor.authoraffiliation[Illescas-Montes,R; Costela-Ruiz,VJ; Melguizo-Rodríguez,L; De Luna-Bertos,E; Ruiz,C; Ramos-Torrecillas,J] Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain. [Illescas-Montes,R; Costela-Ruiz,VJ; Melguizo-Rodríguez,L; De Luna-Bertos,E; Ruiz,C; Ramos-Torrecillas,J] Instituto Investigación Biosanitaria, ibs.Granada, University of Granada, Granada, Spain. [Ruiz,C] Institute of Neuroscience, University of Granada, Granada, Spain.
dc.contributor.funderThis study was supported by research group BIO277 (Junta de Andalucía) and Department of Nursing (University of Granada).
dc.date.accessioned2022-09-28T09:19:43Z
dc.date.available2022-09-28T09:19:43Z
dc.date.issued2021-01-03
dc.description.abstractFibromyalgia (FM) is a highly prevalent syndrome that impairs the quality of life of the patients; however, its diagnosis is complex and mainly centered on pain symptoms. The study of salivary biomarkers has proven highly useful for the diagnosis and prognosis of numerous diseases. The objective of this review was to gather published data on the utilization of salivary biomarkers to facilitate and complement the diagnosis of FM. Salivary biomarkers used in FM diagnosis include cortisol; calgranulin; and the enzymes α-amylase, transaldolase, and phosphoglycerate mutase. Increased serum levels of C-reactive protein, cytokines interleukin 1-β, interleukin 6, interleukin 8, interleukin 10, interleukin 17, tumor necrosis factor α, and various chemokines may serve as salivary biomarkers, given observations of their increased serum levels in patients with FM. Further research is warranted to study in depth the role and performance of biomarkers currently used in FM diagnosis/prognosis and to identify novel salivary biomarkers for this disease.es_ES
dc.description.versionYeses_ES
dc.identifier.citationIllescas-Montes R, Costela-Ruiz VJ, Melguizo-Rodríguez L, De Luna-Bertos E, Ruiz C, Ramos-Torrecillas J. Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia. Diagnostics. 2021 Jan 3;11(1):63es_ES
dc.identifier.doi10.3390/diagnostics11010063es_ES
dc.identifier.essn2075-4418
dc.identifier.pmcPMC7824401
dc.identifier.pmid33401557es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4172
dc.journal.titleDiagnostics
dc.language.isoen
dc.page.number14 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2075-4418/11/1/63/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFibromyalgiaes_ES
dc.subjectSalivaes_ES
dc.subjectBiomarkerses_ES
dc.subjectDiagnosises_ES
dc.subjectFibromialgiaes_ES
dc.subjectBiomarcadoreses_ES
dc.subjectDiagnósticoes_ES
dc.subjectDolores_ES
dc.subjectTerapéuticaes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Diseases::Musculoskeletal Diseases::Muscular Diseases::Fibromyalgiaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive Proteines_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines::Chemokines, CXC::Interleukin-8es_ES
dc.subject.meshMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Lifees_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::Intramolecular Transferases::Phosphotransferases (Phosphomutases)::Phosphoglycerate Mutasees_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Aldehyde-Ketone Transferases::Transaldolasees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Sensation::Paines_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factorses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises_ES
dc.titleApplication of Salivary Biomarkers in the Diagnosis of Fibromyalgiaes_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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