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Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity.

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dc.contributor.authorCarrasco-Benso, Maria P
dc.contributor.authorRivero-Gutierrez, Belen
dc.contributor.authorLopez-Minguez, Jesus
dc.contributor.authorAnzola, Andrea
dc.contributor.authorDiez-Noguera, Antoni
dc.contributor.authorMadrid, Juan A
dc.contributor.authorLujan, Juan A
dc.contributor.authorMartinez-Augustin, Olga
dc.contributor.authorScheer, Frank A J L
dc.contributor.authorGaraulet, Marta
dc.contributor.funderSpanish Government of Economy and Competitiveness
dc.contributor.funderEuropean Regional Development Fund (ERDF)
dc.contributor.funderSeneca Foundation from the Government of Murcia
dc.contributor.funderU.S. National Institutes of Health
dc.date.accessioned2023-01-25T08:33:08Z
dc.date.available2023-01-25T08:33:08Z
dc.date.issued2016-05-19
dc.description.abstractIn humans, insulin sensitivity varies according to time of day, with decreased values in the evening and at night. Mechanisms responsible for the diurnal variation in insulin sensitivity are unclear. We investigated whether human adipose tissue (AT) expresses intrinsic circadian rhythms in insulin sensitivity that could contribute to this phenomenon. Subcutaneous and visceral AT biopsies were obtained from extremely obese participants (body mass index, 41.8 ± 6.3 kg/m(2); 46 ± 11 y) during gastric-bypass surgery. To assess the rhythm in insulin signaling, AKT phosphorylation was determined every 4 h over 24 h in vitro in response to different insulin concentrations (0, 1, 10, and 100 nM). Data revealed that subcutaneous AT exhibited robust circadian rhythms in insulin signaling (P
dc.description.sponsorshipThis study was supported by Spanish Government of Economy and Competitiveness (Grant SAF2014–52480-R) and from European Regional Development Fund (ERDF) (to M.G.), Grant SAF2011–22812 (to O.M.-A.), the Seneca Foundation from the Government of Murcia (15123/PI/10; to M.G.), and by U.S. National Institutes of Health Grants R01-DK099512 (National Institute of Diabetes and Digestive and Kidney Diseases) and R01-HL118601 (National Heart, Lung, and Blood Institute) (to F.A.J.L.S.). Author contributions: M. P. Carrasco-Benso conducted the experiments, performed the cultures, analyzed data, and wrote the paper; B. Rivero-Gutierrez performed Western blot experiments; J. Lopez-Minguez performed the cultures; A. Anzola performed Western blot experiments; A. Diez-Noguera analyzed circadian data; J. A. Madrid gave advice for circadian aspects; J. A. Lujan recruited the study participants and performed the biopsies; O. Martínez-Augustin directed the Western blot experiments; and F. A. J. L. Scheer and M. Garaulet designed research, wrote the paper, and have primary responsibility for final content.
dc.description.versionSi
dc.identifier.citationCarrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA, et al. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J. 2016 Sep;30(9):3117-23.
dc.identifier.doi10.1096/fj.201600269RR
dc.identifier.essn1530-6860
dc.identifier.pmcPMC5001513
dc.identifier.pmid27256623
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001513/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5001513
dc.identifier.urihttp://hdl.handle.net/10668/10148
dc.issue.number9
dc.journal.titleFASEB journal : official publication of the Federation of American Societies for Experimental Biology
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria ibs. GRANADA
dc.page.number3117-3123
dc.provenanceRealizada la curación de contenido 29/07/2024
dc.publisherJohn Wiley & Sons, Inc.
dc.pubmedtypeJournal Article
dc.relation.projectIDSAF2014
dc.relation.projectID52480-R
dc.relation.projectIDSAF2011
dc.relation.projectID22812
dc.relation.projectID15123/PI/10
dc.relation.projectIDR01-DK099512
dc.relation.projectIDR01-HL118601
dc.relation.publisherversionhttps://doi.org/10.1096/fj.201600269RR
dc.rights.accessRightsRestricted Access
dc.subjectdiabetes
dc.subjectglucose tolerance
dc.subjectobesity
dc.subject.decsAdulto
dc.subject.decsEsquema de medicación
dc.subject.decsFosforilación
dc.subject.decsInsulina
dc.subject.decsObesidad
dc.subject.decsPersona de mediana edad
dc.subject.decsProteínas proto-oncogénicas c-akt
dc.subject.decsResistencia a la Insulina
dc.subject.decsRitmo Circadiano
dc.subject.decsSueño
dc.subject.decsTejido adiposo
dc.subject.meshAdipose Tissue
dc.subject.meshAdult
dc.subject.meshCircadian Rhythm
dc.subject.meshDrug Administration Schedule
dc.subject.meshHumans
dc.subject.meshInsulin
dc.subject.meshInsulin Resistance
dc.subject.meshMiddle Aged
dc.subject.meshObesity
dc.subject.meshPhosphorylation
dc.subject.meshProto-Oncogene Proteins c-akt
dc.subject.meshSleep
dc.titleHuman adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number30
dspace.entity.typePublication

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