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Analysis of CXCL12 3 ' UTR G > A polymorphism in colorectal cancer

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dc.contributor.authorHidalgo-Pascual, M
dc.contributor.authorGalan, J J
dc.contributor.authorChaves-Conde, M
dc.contributor.authorRamírez-Armengol, J A
dc.contributor.authorMoreno, C
dc.contributor.authorCalvo, E
dc.contributor.authorPelaez, P
dc.contributor.authorCrespo, C
dc.contributor.authorRuiz, A
dc.contributor.authorRoyo, J L
dc.contributor.authoraffiliation[Hidalgo-Pascual,M; Pelaez,P] Servicio de Cirugía General-B, Hospital Universitario 12 de Octubre, Madrid. [Galan,JJ; Moreno,C; Ruiz,A; Royo,JL] Departamento de Genómica Estructural, Neocodex SL, Sevilla. [Chaves-Conde,M; Calvo,E] Servicio de Oncología Médica, Hospital Universitario Virgen del Rocío, Sevilla. [Ramírez-Armengol,JA] Servicio Central de Endoscopia, Hospital Clínico San Carlos, Madrid. [Crespo,C] Hospital Ramón y Cajal, Madrid, Spain.es
dc.date.accessioned2014-09-03T10:15:28Z
dc.date.available2014-09-03T10:15:28Z
dc.date.issued2007-12-01
dc.descriptionJournal Article; Multicenter Study; Research Support, Non-U.S. Gov't;es
dc.description.abstractColorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed.es
dc.description.versionYeses
dc.identifier.citationHidalgo-Pascual M, Galan JJ, Chaves-Conde M, Ramírez-Armengol JA, Moreno C, Calvo E, et al. Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer. Oncol Rep. 2007 ; 18(6):1583-7es
dc.identifier.essn1791-2431
dc.identifier.issn1021-335X
dc.identifier.pmid17982648
dc.identifier.urihttp://hdl.handle.net/10668/1707
dc.journal.titleOncology Reports
dc.language.isoen
dc.publisherSpandidos Publicationses
dc.relation.publisherversionhttp://www.spandidos-publications.com/or/18/6/1583es
dc.rights.accessRightsopen access
dc.subjectColorectal canceres
dc.subjectSDF1-3'Aes
dc.subjectrs1801157es
dc.subjectCXCL12es
dc.subject3'UTRes
dc.subjectQuimiocina CXCL12es
dc.subjectNeoplasias del Colones
dc.subjectNeoplasias del rectoes
dc.subjectAnálisis de supervivenciaes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Agedes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and overes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines::Chemokines, CXC::Chemokine CXCL12es
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colonic Neoplasmses
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasmses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survivales
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotypees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotidees
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasmses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Weights and Measures::Reference Valueses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysises
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger::Untranslated Regions::3' Untranslated Regionses
dc.titleAnalysis of CXCL12 3 ' UTR G > A polymorphism in colorectal canceres
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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