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Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center.

dc.contributor.authorAlba-Linero, Carmen
dc.contributor.authorRodriguez-Calvo-de-Mora, Marina
dc.contributor.authorLavado-Valenzuela, Rocio
dc.contributor.authorPascual-Cascon, Maria Jesus
dc.contributor.authorMartin-Cerezo, Alejandra Rosario
dc.contributor.authorAlvarez-Perez, Martina
dc.contributor.authorRecio, Luis Vicioso
dc.contributor.authorJerez-Aragones, Jose Manuel
dc.contributor.authorGarcia-Campos, Jose Manuel
dc.date.accessioned2023-02-09T09:37:24Z
dc.date.available2023-02-09T09:37:24Z
dc.date.issued2020-07-24
dc.description.abstractTo characterize anatomical and functional changes in the ocular surface after hematopoietic stem cell transplantation. Three groups of patients were included in the study. Group 1: patients who had undergone allogeneic hematopoietic stem cell transplantation (HSCT) (n = 26). Group 2: patients who developed chronic graft versus host disease (GvHD) after HSCT (n = 14). Group 3: healthy subjects (n = 20). A complete ophthalmological examination was undertaken in all subjects, including Schirmer's test, TBUT (break-up-time) test, Oxford scale, OSDI test, corneal tomography, and conjunctival CD8+ lymphocyte detection. In Branch 1 (comparative analysis before and after HSCT in Group 1), statistically significant differences were found in the following variables: best-corrected visual acuity (BCVA) OD (P = 0.08), OSDI test (P = 0.003), TBUT OU (OD P= 0, OS P= 0.0003), Oxford test OU (OD P= 0.01, OS P= 0.0049), and CD8+ lymphocytes OU (OD P= 0.003, OS P= 0.01). In Branch 2 (comparative analysis between Group 2 and 3), the variables with statistically significant differences (P In our study, statistically significant changes were observed in the OSDI test, TBUT test, Oxford Scale, and the detection of CD8+ lymphocytes in patients who underwent HSCT. Differences were more significant in those patients who had developed GvHD after HSCT compared to those without GvHD.
dc.description.versionSi
dc.identifier.citationAlba-Linero C, Rodriguez Calvo de Mora M, Lavado Valenzuela R, Pascual Cascón MJ, Martín Cerezo AR, Álvarez Pérez M, et al. Ocular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center. Indian J Ophthalmol. 2020 Aug;68(8):1556-1562
dc.identifier.doi10.4103/ijo.IJO_1865_19
dc.identifier.essn1998-3689
dc.identifier.pmcPMC7640859
dc.identifier.pmid32709775
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640859/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.4103/ijo.ijo_1865_19
dc.identifier.urihttp://hdl.handle.net/10668/15997
dc.issue.number8
dc.journal.titleIndian journal of ophthalmology
dc.journal.titleabbreviationIndian J Ophthalmol
dc.language.isoen
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number1556-1562
dc.provenanceRealizada la curación de contenido 29/04/2025
dc.publisherWolters Kluwer - Medknow Publications and Media
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://doi.org/10.4103/ijo.IJO_1865_19
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAllogeneic stem cell transplantation
dc.subjectOSDI test
dc.subjectSchirmer's test
dc.subjectConjunctival CD8+ lymphocyte detection
dc.subject.decsLinfocitos
dc.subject.decsTrasplante de Células Madre Hematopoyéticas
dc.subject.decsAgudeza visual
dc.subject.decsSíndrome de Bronquiolitis Obliterante
dc.subject.meshConjunctiva
dc.subject.meshGraft vs Host Disease
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.meshHumans
dc.subject.meshProspective Studies
dc.subject.meshReferral and Consultation
dc.titleOcular surface characterization after allogeneic stem cell transplantation: A prospective study in a referral center.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number68
dspace.entity.typePublication

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