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A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort.

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dc.contributor.authorChristakoudi, Sofia
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorMuller, David C
dc.contributor.authorFreisling, Heinz
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorOvervad, Kim
dc.contributor.authorSöderberg, Stefan
dc.contributor.authorHäggström, Christel
dc.contributor.authorPischon, Tobias
dc.contributor.authorDahm, Christina C
dc.contributor.authorZhang, Jie
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorMacDonald, Conor
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorMancini, Francesca Romana
dc.contributor.authorKühn, Tilman
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorPeppa, Eleni
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorQuiros, J Ramon
dc.contributor.authorAgudo, Antonio
dc.contributor.authorSanchez-Perez, Maria-Jose
dc.contributor.authorCirera, Lluis
dc.contributor.authorBarricarte-Gurrea, Aurelio
dc.contributor.authorAmiano, Pilar
dc.contributor.authorMemarian, Ensieh
dc.contributor.authorSonestedt, Emily
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorMay, Anne M
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorTong, Tammy Y N
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorNoh, Hwayoung
dc.contributor.authorAglago, Elom K
dc.contributor.authorEllingjord-Dale, Merete
dc.contributor.authorWard, Heather A
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.funderEuropean Commission (DG-SANCO)
dc.contributor.funderInternational Agency for Research on Cancer
dc.contributor.funderEuropean Research Council
dc.contributor.funderHealth Research Fund (FIS)
dc.date.accessioned2023-02-09T09:39:54Z
dc.date.available2023-02-09T09:39:54Z
dc.date.issued2020-08-06
dc.description.abstractAbdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI 
dc.description.sponsorshipThis work was supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer for the coordination of EPIC. The national cohorts were supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer; Institut Gustave Roussy; Mutuelle Générale de l’Education Nationale and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid; German Cancer Research Center (DKFZ); Federal Ministry of Education and Research (BMBF); Deutsche Krebshilfe; Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF) and Statistics Netherlands (The Netherlands); European Research Council (ERC-2009-AdG 232997) and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS) (PI13/00061 to Granada, PI13/01162 to EPIC-Murcia); Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra and the Catalan Institute of Oncology (Barcelona) (Spain); Swedish Cancer Society; Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk and MR/M012190/1 to EPIC-Oxford) (United Kingdom). The funders had no role in the design and conduct of the study, the collection, analysis, and interpretation of the data, or the preparation, review, and approval of the manuscript, or in the decision to submit the manuscript for publication.
dc.description.versionSi
dc.identifier.citationChristakoudi S, Tsilidis KK, Muller DC, Freisling H, Weiderpass E, Overvad K, et al. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort. Sci Rep. 2020 Sep 3;10(1):14541
dc.identifier.doi10.1038/s41598-020-71302-5
dc.identifier.essn2045-2322
dc.identifier.pmcPMC7471961
dc.identifier.pmid32883969
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471961/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41598-020-71302-5.pdf
dc.identifier.urihttp://hdl.handle.net/10668/16203
dc.issue.number1
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number14
dc.publisherNature Publishing Group
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDERC-2009-AdG 232997
dc.relation.projectIDPI13/00061
dc.relation.projectIDPI13/01162
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-020-71302-5
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBody Mass Index
dc.subjectCohort Studies
dc.subjectEurope
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subject.decsCircunferencia de la cintura
dc.subject.decsFactores de riesgo
dc.subject.decsModelos de riesgos proporcionales
dc.subject.decsObesidad abdominal
dc.subject.decsRelación cintura-cadera
dc.subject.meshObesity, Abdominal
dc.subject.meshProportional Hazards Models
dc.subject.meshRisk Factors
dc.subject.meshWaist Circumference
dc.subject.meshWaist-Hip Ratio
dc.titleA Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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