Publication: Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean.
dc.contributor.author | Pech-Puch, Dawrin | |
dc.contributor.author | Rodríguez, Jaime | |
dc.contributor.author | Cautain, Bastien | |
dc.contributor.author | Sandoval-Castro, Carlos Alfredo | |
dc.contributor.author | Jiménez, Carlos | |
dc.date.accessioned | 2023-01-25T13:36:49Z | |
dc.date.available | 2023-01-25T13:36:49Z | |
dc.date.issued | 2019-07-16 | |
dc.description.abstract | Two new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3,13(16),14-trien-2-one (3), 3β,19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (4) and spongian diterpene 17 (5), the furanoditerpene ambliol C (6), and the sesterterpene scalarin (7), were isolated from the methanolic extract of the sponge Spongia tubulifera, collected in the Mexican Caribbean. The planar structures of the new compounds were elucidated by 1D/2D NMR and IR spectroscopic analysis, high resolution electrospray mass spectrometry (HRESIMS), and comparison of their spectral data with those reported in the literature. Absolute configurations were determined by comparison of the experimental electronic circular dichroism (ECD) spectrum with those calculated by time-dependent density functional theory (TDDFT). Compounds 1, 4, and 6 displayed weak cytotoxic activity against different human tumour cell lines. | |
dc.identifier.doi | 10.3390/md17070416 | |
dc.identifier.essn | 1660-3397 | |
dc.identifier.pmc | PMC6669439 | |
dc.identifier.pmid | 31315183 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669439/pdf | |
dc.identifier.unpaywallURL | https://www.mdpi.com/1660-3397/17/7/416/pdf?version=1563255928 | |
dc.identifier.uri | http://hdl.handle.net/10668/14250 | |
dc.issue.number | 7 | |
dc.journal.title | Marine drugs | |
dc.journal.titleabbreviation | Mar Drugs | |
dc.language.iso | en | |
dc.organization | Fundación MEDINA (Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía) | |
dc.organization | Fundación MEDINA | |
dc.pubmedtype | Journal Article | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | ECD-TDDFT | |
dc.subject | Spongia tubulifera | |
dc.subject | cytotoxicity | |
dc.subject | marine sponge | |
dc.subject | spongian furanoditerpenes | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Caribbean Region | |
dc.subject.mesh | Cell Line, Tumor | |
dc.subject.mesh | Cell Survival | |
dc.subject.mesh | Diterpenes | |
dc.subject.mesh | Drug Screening Assays, Antitumor | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Magnetic Resonance Spectroscopy | |
dc.subject.mesh | Marine Toxins | |
dc.subject.mesh | Mexico | |
dc.subject.mesh | Molecular Structure | |
dc.subject.mesh | Porifera | |
dc.title | Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean. | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 17 | |
dspace.entity.type | Publication |
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