Publication:
Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean.

dc.contributor.authorPech-Puch, Dawrin
dc.contributor.authorRodríguez, Jaime
dc.contributor.authorCautain, Bastien
dc.contributor.authorSandoval-Castro, Carlos Alfredo
dc.contributor.authorJiménez, Carlos
dc.date.accessioned2023-01-25T13:36:49Z
dc.date.available2023-01-25T13:36:49Z
dc.date.issued2019-07-16
dc.description.abstractTwo new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3,13(16),14-trien-2-one (3), 3β,19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (4) and spongian diterpene 17 (5), the furanoditerpene ambliol C (6), and the sesterterpene scalarin (7), were isolated from the methanolic extract of the sponge Spongia tubulifera, collected in the Mexican Caribbean. The planar structures of the new compounds were elucidated by 1D/2D NMR and IR spectroscopic analysis, high resolution electrospray mass spectrometry (HRESIMS), and comparison of their spectral data with those reported in the literature. Absolute configurations were determined by comparison of the experimental electronic circular dichroism (ECD) spectrum with those calculated by time-dependent density functional theory (TDDFT). Compounds 1, 4, and 6 displayed weak cytotoxic activity against different human tumour cell lines.
dc.identifier.doi10.3390/md17070416
dc.identifier.essn1660-3397
dc.identifier.pmcPMC6669439
dc.identifier.pmid31315183
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669439/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1660-3397/17/7/416/pdf?version=1563255928
dc.identifier.urihttp://hdl.handle.net/10668/14250
dc.issue.number7
dc.journal.titleMarine drugs
dc.journal.titleabbreviationMar Drugs
dc.language.isoen
dc.organizationFundación MEDINA (Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía)
dc.organizationFundación MEDINA
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectECD-TDDFT
dc.subjectSpongia tubulifera
dc.subjectcytotoxicity
dc.subjectmarine sponge
dc.subjectspongian furanoditerpenes
dc.subject.meshAnimals
dc.subject.meshCaribbean Region
dc.subject.meshCell Line, Tumor
dc.subject.meshCell Survival
dc.subject.meshDiterpenes
dc.subject.meshDrug Screening Assays, Antitumor
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Spectroscopy
dc.subject.meshMarine Toxins
dc.subject.meshMexico
dc.subject.meshMolecular Structure
dc.subject.meshPorifera
dc.titleCytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number17
dspace.entity.typePublication

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