Publication: Neoadjuvant Biologic Therapy in the Surgical Management of Patients with Hidradenitis Suppurativa: A Cohort Study
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Date
2020-08-19
Authors
Salvador-Rodriguez, Luis
Cuenca-Barrales, Carlos
Arias-Santiago, Salvador
Molina-Leyva, Alejandro
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Society for Publication of Acta Dermato-Venereologica
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Abstract
Hidradenitis suppurativa (HS) is a chronic skin disease characterized by recurrent flares of nodules, abscesses and fistulae, predominantly in the apocrine gland-bearing areas. These symptoms progress to scarring if not adequately treated, leading to functional limitations (1). Disease management is challenging, the 2 mainstays of treatment being biologic drugs and surgery. However, scientific evidence regarding the combined use of both therapies is scarce and is limited to a few studies (2–4). A clinical trial (SHARPS Study) is in progress on the safety and efficacy of peri-surgically administered adalimumab, but the results are not yet available (5).
The objectives of this study were: to assess the clinical features of patients with HS undergoing surgery with neoadjuvant biologic treatment; to explore the complications of this combined approach; and to compare recurrence rates at 24 weeks after surgery between patients on concomitant biologic treatment and those who are not on biologic treatment.
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MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy::Neoadjuvant Therapy
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Suppuration::Hidradenitis Suppurativa
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy::Neoadjuvant Therapy
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Suppuration::Hidradenitis Suppurativa
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CIE Terms
Keywords
Neoadjuvant therapy, Hidradenitis suppurativa, Patient care, Patient care management, Cohort studies, Biological therapy, Atención al paciente, Terapia neoadyuvante, Hidradenitis supurativa, Manejo de atención al paciente, Estudios de cohortes, Terapia biológica
Citation
Salvador-Rodriguez L, Cuenca-Barrales C, Arias-Santiago S, Molina-Leyva A. Neoadjuvant Biologic Therapy in the Surgical Management of Patients with Hidradenitis Suppurativa: A Cohort Study. Acta Derm Venereol. 2020 Sep 8;100(16):adv00257.