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Correction to: Utility of pulmonary ultrasound to identify interstitial lung disease in patients with rheumatoid arthritis.

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Date

2021-02-21

Authors

Mena-Vazquez, Natalia
Jimenez-Nuñez, Francisco Gabriel
Godoy-Navarrete, Francisco Javier
Manrique-Arija, Sara
Aguilar-Hurtado, Maria Carmen
Romero-Barco, Carmen Maria
Ureña-Garnica, Inmaculada
Espildora, F
Padin-Martin, Maria Isabel
Fernandez-Nebro, Antonio

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Springer
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Abstract

Objectives To analyze the diagnostic utility of lung ultrasound (US) to detect interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients comparing with high-resolution computed tomography (HRCT) Patients and methods We performed a cross-sectional, observational study in patients with RA-ILD (cases) controlled with a group of RA patients without ILD (controls) paired by sex, age, and time of disease evolution. Patients were assessed using HRCT, PFT, and US. The main variables were B-line number, evaluation of the lung-US score already described, pleural irregularities, and A pattern US lost. ROC curve analysis was performed to establish the cut-off point of the US B-lines number for detecting the presence of significant RA–ILD in relation to HRCT, and logistic regression analysis was performed to identify the intercostal spaces. Results Seventy-one patients were included, 35 (49.2%) with ILD-RA and 36 (50.8%) RA controls. Regarding US score, we found that the detection of 5.5 lines in a reduced score of 8 intercostal spaces had a sensitivity = 62.2%, specificity = 91.3%, PPV = 88.4%, and NPV = 69.5%. In multivariate analysis, the intercostal spaces which showed independent association with ILD were 3rd right anterior axillary space (OR [IC 95%] 19.0 [1.3–27.5]), 8th right posterior axillary space (OR [IC 95%] 0.04 [0.0–0.6]), 8th right subscapular space (OR [IC 95%] 16.5 [1.8–45.5]), 9th right paravertebral space (OR [IC 95%] 7.11 [1.0–37.1]), and 2nd left clavicular middle space (OR [IC 95%] 21.9 [1.26–37.8]). Conclusions Lung ultrasound could be a useful tool for ILD diagnosis associated with rheumatoid arthritis. A 8-space reduced score showed a similar total predictive capacity than 72-space score.

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MeSH Terms

Logistic Models
Lung Diseases, Interstitial
Arthritis, Rheumatoid
Multivariate Analysis
Tomography

DeCS Terms

Pulmón
Artritis Reumatoide
Sensibilidad y Especificidad
Enfermedades Pulmonares Intersticiales
Análisis Multivariante
Curva ROC

CIE Terms

Keywords

Lung, Arthritis, Rheumatoid, Sensitivity and Specificity, Lung Diseases, Interstitial, Tomography

Citation

Mena-Vázquez N, Jimenez-Núñez FG, Godoy-Navarrete FJ, Manrique-Arija S, Aguilar-Hurtado MC, Romero-Barco CM, et al. Utility of pulmonary ultrasound to identify interstitial lung disease in patients with rheumatoid arthritis. Clin Rheumatol. 2021 Jun;40(6):2377-2385