Publication:
CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer.

dc.contributor.authorOlivares-Urbano, Maria Auxiliadora
dc.contributor.authorGriñan-Lison, Carmen
dc.contributor.authorMarchal, Juan Antonio
dc.contributor.authorNuñez, Maria Isabel
dc.contributor.funderMinisterio de Ciencia, Innovacion y Universidades (MICIU)
dc.contributor.funderJunta de Andalucia
dc.contributor.funderEuropean Union (EU)
dc.contributor.funderChair "Doctors Galera-Requena in cancer stem cell research"
dc.date.accessioned2023-02-09T09:36:50Z
dc.date.available2023-02-09T09:36:50Z
dc.date.issued2020-07-09
dc.description.abstractRadiotherapy (RT) is a modality of oncologic treatment that can be used to treat approximately 50% of all cancer patients either alone or in combination with other treatment modalities such as surgery, chemotherapy, immunotherapy, and therapeutic targeting. Despite the technological advances in RT, which allow a more precise delivery of radiation while progressively minimizing the impact on normal tissues, issues like radioresistance and tumor recurrence remain important challenges. Tumor heterogeneity is responsible for the variation in the radiation response of the different tumor subpopulations. A main factor related to radioresistance is the presence of cancer stem cells (CSC) inside tumors, which are responsible for metastases, relapses, RT failure, and a poor prognosis in cancer patients. The plasticity of CSCs, a process highly dependent on the epithelial-mesenchymal transition (EMT) and associated to cell dedifferentiation, complicates the identification and eradication of CSCs and it might be involved in disease relapse and progression after irradiation. The tumor microenvironment and the interactions of CSCs with their niches also play an important role in the response to RT. This review provides a deep insight into the characteristics and radioresistance mechanisms of CSCs and into the role of CSCs and tumor microenvironment in both the primary tumor and metastasis in response to radiation, and the radiobiological principles related to the CSC response to RT. Finally, we summarize the major advances and clinical trials on the development of CSC-based therapies combined with RT to overcome radioresistance. A better understanding of the potential therapeutic targets for CSC radiosensitization will provide safer and more efficient combination strategies, which in turn will improve the live expectancy and curability of cancer patients.
dc.description.versionSi
dc.identifier.citationOlivares-Urbano MA, Griñán-Lisón C, Marchal JA, Núñez MI. CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer. Cells. 2020 Jul 9;9(7):1651.
dc.identifier.doi10.3390/cells9071651
dc.identifier.essn2073-4409
dc.identifier.pmcPMC7407195
dc.identifier.pmid32660072
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407195/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2073-4409/9/7/1651/pdf
dc.identifier.urihttp://hdl.handle.net/10668/15929
dc.issue.number7
dc.journal.titleCells
dc.journal.titleabbreviationCells
dc.language.isoen
dc.organizationIBS
dc.page.number35
dc.provenanceRealizada la curación de contenido 21/04/2025
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeReview
dc.relation.projectIDRTI2018-101309-B-C2
dc.relation.projectIDPIE16-00045
dc.relation.projectIDDTS19/00145
dc.relation.projectIDSOMM17/6109/UGR (UCE-PP2017-3)
dc.relation.projectIDCMC-CTS963
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=cells9071651
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCSC intratumoral radiosensitivity heterogeneity
dc.subjectCSC metabolism
dc.subjectCSC niche
dc.subjectaccelerated repopulation
dc.subjectradiation resistance
dc.subjectsignaling pathways
dc.subjecttumor microenvironment
dc.subject.decsNeoplasias
dc.subject.decsRadiación
dc.subject.decsRecurrencia
dc.subject.decsMetástasis de la Neoplasia
dc.subject.decsMicroambiente Tumoral
dc.subject.decsCélulas Madre Neoplásicas
dc.subject.decsRadioterapia
dc.subject.decsDesdiferenciación celular
dc.subject.decsInmunoterapia
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshNeoplastic Stem Cells
dc.subject.meshRadiation Tolerance
dc.subject.meshRadiotherapy
dc.subject.meshInstituto de Salud Carlos III Spanish Government
dc.titleCSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer.
dc.typeReview
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
PMC7407195.pdf
Size:
1.18 MB
Format:
Adobe Portable Document Format