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Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

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dc.contributor.authorHmadcha, Abdelkrim
dc.contributor.authorMartin-Montalvo, Alejandro
dc.contributor.authorGauthier, Benoit R.
dc.contributor.authorSoria, Bernat
dc.contributor.authorCapilla-Gonzalez, Vivian
dc.contributor.authoraffiliation[Hmadcha,A; Martin-Montalvo,A; Gauthier,BR; Capilla-Gonzalez,V] Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Pablo de Olavide University, University of Seville, CSIC, Seville, Spain. [Hmadcha,A; Gauthier,BR; Soria,B] Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Institute of Health Carlos III, Madrid, Spain. [Soria,B] School of Medicine, Miguel Hernández University, Alicante, Spain. [Soria,B] Pablo de Olavide University, Seville, Spain.
dc.contributor.funderThe authors received financial support from the Andalusian Regional Ministry of Health (PI-0272-2017), the Institute of Health Carlos III, and the Spanish Ministry of Science, Innovation and University, co-funded by Fondos FEDER (CD16/00118, CP19/00046, PI16/00259, BFU2017-83588-P, CP14/00105, PI18/01590, PI17/02104, PIC18/0010, and IC19/0052), the JDRF (2-SRA-2019-837-S-B), and the crowdfunding platform PRECIPITA of the Spanish Foundation for Science and Technology (2018-000237).
dc.date.accessioned2022-06-09T10:48:22Z
dc.date.available2022-06-09T10:48:22Z
dc.date.issued2020-02-05
dc.description.abstractMesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders, cardiac ischemia, diabetes, and bone and cartilage diseases. However, the therapeutic potential of MSCs in cancer is still controversial. While some studies indicate that MSCs may contribute to cancer pathogenesis, emerging data reported the suppressive effects of MSCs on cancer cells. Because of this reality, a sustained effort to understand when MSCs promote or suppress tumor development is needed before planning a MSC-based therapy for cancer. Herein, we provide an overview on the therapeutic application of MSCs for regenerative medicine and the processes that orchestrates tissue repair, with a special emphasis placed on cancer, including central nervous system tumors. Furthermore, we will discuss the current evidence regarding the double-edged sword of MSCs in oncological treatment and the latest advances in MSC-based anti-cancer agent delivery systems.es_ES
dc.description.versionYeses_ES
dc.identifier.citationHmadcha A, Martin-Montalvo A, Gauthier BR, Soria B, Capilla-Gonzalez V. Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy. Front Bioeng Biotechnol. 2020 Feb 5;8:43es_ES
dc.identifier.doi10.3389/fbioe.2020.00043es_ES
dc.identifier.essn2296-4185
dc.identifier.pmcPMC7013101
dc.identifier.pmid32117924es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3685
dc.journal.titleFrontiers in Bioengineering and Biotechnology
dc.language.isoen
dc.page.number13 p.
dc.publisherFrontierses_ES
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fbioe.2020.00043/fulles_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMesenchymal stem cellses_ES
dc.subjectCanceres_ES
dc.subjectCell therapyes_ES
dc.subjectTherapeutic agentses_ES
dc.subjectAnti-tumor activityes_ES
dc.subjectCélulas madre mesenquimatosases_ES
dc.subjectNeoplasiases_ES
dc.subjectTratamiento basado en trasplante de células y tejidoses_ES
dc.subjectTerapéuticaes_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Health Occupations::Medicine::Regenerative Medicinees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Mesenchymal Stem Cell Transplantationes_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeuticses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cellses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cellses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Reconstructive Surgical Procedures::Guided Tissue Regenerationes_ES
dc.titleTherapeutic Potential of Mesenchymal Stem Cells for Cancer Therapyes_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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