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Clinic-epidemiologic study of human infection by Granada virus, a new phlebovirus within the sandfly fever Naples serocomplex.

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dc.contributor.authorNavarro-Marí, José María
dc.contributor.authorGómez-Camarasa, Cristina
dc.contributor.authorPérez-Ruiz, Mercedes
dc.contributor.authorSanbonmatsu-Gámez, Sara
dc.contributor.authorPedrosa-Corral, Irene
dc.contributor.authorJiménez-Valera, María
dc.contributor.authoraffiliationServicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spaines
dc.contributor.funderThis study was supported in part by funds from a research project (0328/2009; Junta de Andalucía, Spain
dc.date.accessioned2014-06-04T11:26:03Z
dc.date.available2014-06-04T11:26:03Z
dc.date.issued2013-05
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractGranada virus (GRV), a new phlebovirus within the Naples serocomplex, has been recently described in phlebotomine sandflies from Spain. The presence of anti-GRV immunoglobulin G (IgG) antibodies was investigated by indirect fluorescence assay (IFA) and neutralization test (NT) in 920 serum samples from the Granada population. By IFA, an overall GRV seroprevalence of 15.8% (N = 145) was observed, significantly increasing up to 65 years. NT was positive in 18% of anti-GRV IFA-positive samples. IgG antibodies against Toscana virus (TOSV), a hyperendemic phlebovirus within Granada province, were detected in 40% of anti-GRV-positive cases. Anti-GRV IgM antibodies were detected in 36 (6.6%) of 547 acute-phase serum samples from individuals with febrile illness, exanthema, and/or acute respiratory infection. All positives were anti-TOSV IgM-negative. GRV may infect humans, with most cases being asymptomatic. The codetection of anti-GRV and anti-TOSV IgG antibodies could be attributable to cross-reactivity or exposure to the same transmission vector.es
dc.description.versionYeses
dc.identifier.citationNavarro-Marí JM, Gómez-Camarasa C, Pérez-Ruiz M, Sanbonmatsu-Gámez S, Pedrosa-Corral I, Jiménez-Valera M. Clinic-epidemiologic study of human infection by Granada virus, a new phlebovirus within the sandfly fever Naples serocomplex. Am. J. Trop. Med. Hyg.. 2013 ; 88(5):1003-6es
dc.identifier.doi10.4269/ajtmh.12-0732
dc.identifier.essn1476-1645
dc.identifier.issn0002-9637
dc.identifier.pmid23419365
dc.identifier.urihttp://hdl.handle.net/10668/1624
dc.journal.titleThe American Journal of Tropical Medicine and Hygiene
dc.language.isoen
dc.publisherAmerican Society of Tropical Medicine and Hygienees
dc.relation.publisherversionhttp://www.ajtmh.org/content/88/5/1003.abstractes
dc.rights.accessRightsopen access
dc.subjectImmunoglobulina Ges
dc.subjectImmunoglobulina Mes
dc.subjectAnticuerpos víricoses
dc.subjectFiebre por Flebótomoses
dc.subjectPhleboviruses
dc.subjectPsychodidaees
dc.subjectVirus de Nápoles de la Fiebre de la Mosca de los Arenaleses
dc.subjectEspañaes
dc.subjectEstudios Seroepidemiológicoses
dc.subjectAndaluciaes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Agedes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodieses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Antigen-Antibody Reactions::Cross Reactionses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin Ges
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin Mes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::Arbovirus Infections::Phlebotomus Feveres
dc.subject.meshMedical Subject Headings::Organisms::Viruses::RNA Viruses::Bunyaviridae::Phleboviruses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Arthropods::Insects::Diptera::Psychodidaees
dc.subject.meshMedical Subject Headings::Organisms::Viruses::RNA Viruses::Bunyaviridae::Phlebovirus::Sandfly fever Naples viruses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Seroepidemiologic Studieses
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Serum Globulins::Immunoglobulins::Antibodies::Antibodies, Virales
dc.titleClinic-epidemiologic study of human infection by Granada virus, a new phlebovirus within the sandfly fever Naples serocomplex.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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