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The role of exosomes on colorectal cancer: A review.

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dc.contributor.authorRuiz-Lopez, Lidia
dc.contributor.authorBlancas, Isabel
dc.contributor.authorGarrido, Jose M
dc.contributor.authorMut-Salud, Nuria
dc.contributor.authorMoya-Jodar, Marta
dc.contributor.authorOsuna, Antonio
dc.contributor.authorRodriguez-Serrano, Fernando
dc.contributor.funderMinistry of Economy and Cometitiveness
dc.contributor.funderRegional Govern-ment of Andalusia
dc.contributor.funderRamón Areces Foundation (Madrid, Spain).
dc.date.accessioned2023-01-25T10:01:31Z
dc.date.available2023-01-25T10:01:31Z
dc.date.issued2017-11-10
dc.description.abstractExosomes are extracellular microvesicles released from cells, which are involved in many biological and pathological processes, mainly because of their role in intercellular communication. Exosomes derived from colorectal cancer (CRC) cells are related to oncogenesis, tumor cell survival, chemo-resistance, and metastasis. The role of the exosomes in these processes involves the transfer of proteins, RNAs, or mutant versions of proto-oncogenes to the target cells. In recent years, great efforts have been made to identify useful biomarkers in CRC exosomes for diagnosis, prediction of prognosis, and treatment response. This review focuses on recent studies on CRC exosomes, considering isolation, cargo, biomarkers, and the effects of exosomes on the development and progression of CRC, including resistance to antitumor therapy.
dc.description.sponsorshipThis study was supported by the Ministry of Economy and Com-petitiveness (Project CTQ2014-56611-R), the Regional Govern-ment of Andalusia (Project P11-CTS-7651), and Ramón ArecesFoundation (Madrid, Spain).
dc.description.versionSi
dc.identifier.citationRuiz-López L, Blancas I, Garrido JM, Mut-Salud N, Moya-Jódar M, Osuna A, et al. The role of exosomes on colorectal cancer: A review. J Gastroenterol Hepatol. 2018 Apr;33(4):792-799.
dc.identifier.doi10.1111/jgh.14049
dc.identifier.essn1440-1746
dc.identifier.pmid29156509
dc.identifier.unpaywallURLhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgh.14049
dc.identifier.urihttp://hdl.handle.net/10668/11820
dc.issue.number4
dc.journal.titleJournal of gastroenterology and hepatology
dc.journal.titleabbreviationJ Gastroenterol Hepatol
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario San Cecilio
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number792-799
dc.provenanceRealizada la curación de contenido 23/07/2024
dc.publisherJohn Wiley & Sons, Inc.
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.relation.projectIDCTQ2014-6611-R
dc.relation.projectIDP11-CTS-7651
dc.relation.publisherversionhttps://doi.org/10.1111/jgh.14049
dc.rights.accessRightsRestricted Access
dc.subjectbiomarkers
dc.subjectcolorectal cancer
dc.subjectexosomes
dc.subjectintercellular communication
dc.subjectoncogenic transformation
dc.subject.decsARN neoplásico
dc.subject.decsBiomarcadores de tumor
dc.subject.decscarcinogénesis
dc.subject.decsExosomas
dc.subject.decsMutación
dc.subject.decsNeoplasias colorrectales
dc.subject.decsProgresión de la enfermedad
dc.subject.decsPronóstico
dc.subject.decsProteínas de neoplasias
dc.subject.decsProto-oncogenes
dc.subject.decsResistencia a antineoplásicos
dc.subject.decsTransporte de proteínas
dc.subject.meshBiomarkers, Tumor
dc.subject.meshCarcinogenesis
dc.subject.meshColorectal Neoplasms
dc.subject.meshDisease Progression
dc.subject.meshDrug Resistance, Neoplasm
dc.subject.meshExosomes
dc.subject.meshHumans
dc.subject.meshMutation
dc.subject.meshNeoplasm Proteins
dc.subject.meshPrognosis
dc.subject.meshProtein Transport
dc.subject.meshProto-Oncogenes
dc.subject.meshRNA, Neoplasm
dc.titleThe role of exosomes on colorectal cancer: A review.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number33
dspace.entity.typePublication

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