Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry.

Abstract

Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system. Sex and previous gestations might have a prognostic impact on 1-year mortality in patients admitted with HF. We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF. Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values In patients admitted with HF, female sex and the number of previous pregnancies are independently associated with better 1-year survival.