Publication: Sex-specific cognitive abnormalities in early-onset psychosis.
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Date
2016-01-09
Authors
Ruiz-Veguilla, Miguel
Moreno-Granados, Josefa
Salcedo-Marin, Maria D
Barrigon, Maria L
Blanco-Morales, Maria J
Igunza, Evelio
Cañabate, Anselmo
Garcia, Maria D
Guijarro, Teresa
Diaz-Atienza, Francisco
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Abstract
Brain maturation differs depending on the area of the brain and sex. Girls show an earlier peak in maturation of the prefrontal cortex. Although differences between adult females and males with schizophrenia have been widely studied, there has been less research in girls and boys with psychosis. The purpose of this study was to examine differences in verbal and visual memory, verbal working memory, auditory attention, processing speed, and cognitive flexibility between boys and girls. We compared a group of 80 boys and girls with first-episode psychosis to a group of controls. We found interactions between group and sex in verbal working memory (p = 0.04) and auditory attention (p = 0.01). The female controls showed better working memory (p = 0.01) and auditory attention (p = 0.001) than males. However, we did not find any sex differences in working memory (p = 0.91) or auditory attention (p = 0.93) in the psychosis group. These results are consistent with the presence of sex-modulated cognitive profiles at first presentation of early-onset psychosis.
Description
MeSH Terms
Adolescent
Case-Control Studies
Child
Cognition Disorders
Female
Humans
Male
Memory, Short-Term
Neuropsychological Tests
Prefrontal Cortex
Schizophrenia
Schizophrenic Psychology
Sex Factors
Case-Control Studies
Child
Cognition Disorders
Female
Humans
Male
Memory, Short-Term
Neuropsychological Tests
Prefrontal Cortex
Schizophrenia
Schizophrenic Psychology
Sex Factors