Publication:
Glycemic control and maternal and fetal outcomes in pregnant women with type 1 diabetes according to the type of basal insulin.

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Date

2016-09-08

Authors

Chico, A
Herranz, L
Corcoy, R
Ramirez, O
Goya, M M
Bellart, J
Gonzalez-Romero, S
Codina, M
Sanchez, P
Cortazar, A

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Elsevier
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Abstract

To examine the potential role of the type of basal insulin on glycemic control and maternal and foetal outcomes in pregnant women with type 1 diabetes (T1DM). Retrospective cohort study of pregnancies attended at 18 Spanish tertiary hospitals. T1DM, singleton pregnancies, delivery between 2002-2010, and use of the same basal and prandial insulin from before pregnancy until delivery. A total of 1534 pregnancies were included. The basal insulin most commonly used was Neutral Protamine Hagedorn (NPH) (51.7%), followed by glargine (23.2%) and continuous subcutaneous insulin infusion (CSII) (21.1%). CSII users had longer diabetes duration. Multiple logistic regression analysis showed that CSII was independently associated with lower doses of insulin, higher glycated haemoglobin (HbA1c) in all trimesters, and higher rates of miscarriage, preterm birth and neonatal hypoglycemia. Glargine was related to a higher risk of preterm birth and a small-for-gestational age infant (SGA). The odds ratios (OR) of the associations between insulin type and clinical outcomes (from 0.642 to 4.894) have a relevant magnitude. In this observational study of pregnant women with T1DM, the type of basal insulin was independently associated with metabolic variables and foetal outcomes.

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MeSH Terms

Adult
Blood Glucose
Diabetes Mellitus, Type 1
Female
Glycated Hemoglobin
Humans
Hypoglycemic Agents
Infant, Newborn
Insulin
Male
Pregnancy
Pregnancy Outcome
Pregnancy in Diabetics
Retrospective Studies

DeCS Terms

Embarazo
Insulina Glargina
Edad Gestacional
Aborto Espontáneo
Diabetes Mellitus Tipo 1
Control Glucémico

CIE Terms

Keywords

Continuous subcutaneous insulin infusion, Glycated haemoglobin, Insulin analogue, Perinatal outcomes, Pregnancy, Type 1 diabetes

Citation

Chico A, Herranz L, Corcoy R, Ramírez O, Goya MM, Bellart J, et al. Glycemic control and maternal and fetal outcomes in pregnant women with type 1 diabetes according to the type of basal insulin. Eur J Obstet Gynecol Reprod Biol. 2016 Nov;206:84-91