The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology

Quiñones-Vico, María I.; Sanabria-de la Torre, Raquel; Sánchez-Díaz, Manuel; Sierra-Sánchez, Álvaro; Montero-Vílchez, Trinidad; Fernández-González, Ana; Arias-Santiago, Salvador

Publication:
The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology

dc.contributor.author	Quiñones-Vico, María I.
dc.contributor.author	Sanabria-de la Torre, Raquel
dc.contributor.author	Sánchez-Díaz, Manuel
dc.contributor.author	Sierra-Sánchez, Álvaro
dc.contributor.author	Montero-Vílchez, Trinidad
dc.contributor.author	Fernández-González, Ana
dc.contributor.author	Arias-Santiago, Salvador
dc.contributor.authoraffiliation	[Quiñones-Vico,MI; Sanabria-de la Torre,R; Sierra-Sánchez,Á; Fernández-González,A; Arias-Santiago,S] Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Granada, Spain. [Quiñones-Vico,MI; Sanabria-de la Torre,R; Sánchez-Díaz,M; Sierra-Sánchez,Á; Montero-Vílchez,T; Fernández-González,A; Arias-Santiago,S] Granada Biosanitary Research Institute (ibs. GRANADA), Granada, Spain. [Quiñones-Vico,MI; Sanabria-de la Torre,R; Sierra-Sánchez,Á; Fernández-González,A; Arias-Santiago,S] Andalusian Network for the Design and Translation of Advanced Therapies, Seville, Spain. [Quiñones-Vico,MI; Arias-Santiago,S] Department of Dermatology, School of Medicine, University of Granada, Granada, Spain. [Sánchez-Díaz,M; Montero-Vílchez,T; Arias-Santiago,S] Department of Dermatology, Virgen de las Nieves University Hospital, Granada, Spain.
dc.contributor.funder	This study has been funded by the Carlos III Health Institute of Spain through the PI13/02576 and PI17/02083 projects [co funded by European Regional Development Fund “A way to make Europe” and Andalusian Regional Government Finance (SAS PI-0458-2016)]. The work of MQ-V was supported by a predoctoral fellowship (BOE 22/10/2019) from the Spanish Ministry of Science, Innovation and Universities.
dc.date.accessioned	2022-09-28T07:18:13Z
dc.date.available	2022-09-28T07:18:13Z
dc.date.issued	2021-04-07
dc.description.abstract	The skin is the largest organ of the human body and its main functions include providing protection from external harmful agents, regulating body temperature, and homeostatic maintenance. Skin injuries can damage this important barrier and its functions so research focuses on approaches to accelerate wound healing and treat inflammatory skin diseases. Due to their regenerative and immunomodulatory properties, mesenchymal stromal cells (MSCs) have been reported to play a significant role in skin repair and regeneration. However, it seems that the secretome of these cells and exosomes in particular may be responsible for their functions in skin regeneration and the immunomodulation field. The present review aims to gather the available information about the role of MSC-derived exosomes for both in vitro and in vivo models of different skin conditions and to highlight the need for further research in order to overcome any limitations for clinical translation.	en
dc.description.version	Yes	es_ES
dc.identifier.citation	Quiñones-Vico MI, Sanabria-de la Torre R, Sánchez-Díaz M, Sierra-Sánchez Á, Montero-Vílchez T, Fernández-González A, et al. The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology. Front Cell Dev Biol. 2021 Apr 7;9:647012	es_ES
dc.identifier.doi	10.3389/fcell.2021.647012	es_ES
dc.identifier.essn	2296-634X
dc.identifier.pmc	PMC8058372
dc.identifier.pmid	33898436
dc.identifier.uri	http://hdl.handle.net/10668/4168
dc.journal.title	Frontiers in Cell and Developmental Biology
dc.language.iso	en
dc.organization	RAdytTA - Red Andaluza de diseño y traslación de terapias avanzadas
dc.page.number	18 p.
dc.publisher	Frontiers	es_ES
dc.relation.publisherversion	https://www.frontiersin.org/articles/10.3389/fcell.2021.647012/full	es_ES
dc.rights	Atribución 4.0 Internacional	*
dc.rights.accessRights	open access
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Exosomes-based therapy	es_ES
dc.subject	Immunomodulation	es_ES
dc.subject	Mesenchymal stem cell-derived exosomes	es_ES
dc.subject	Regenerative medicine	es_ES
dc.subject	Skin autoimmune diseases	es_ES
dc.subject	Skin wound healing	es_ES
dc.subject	Exosomas	es_ES
dc.subject	Terapéutica	es_ES
dc.subject	Inmunomodulación	es_ES
dc.subject	Células madre mesenquimatosas	es_ES
dc.subject	Medicina regenerativa	es_ES
dc.subject	Enfermedades autoinmunes	es_ES
dc.subject	Piel	es_ES
dc.subject	Cicatrización de heridas	es_ES
dc.subject.mesh	Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Transport Vesicles::Exosomes	es_ES
dc.subject.mesh	Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Vital Signs::Body Temperature	es_ES
dc.subject.mesh	Medical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Anthropology::Anthropology, Cultural::Culture::Human Body	es_ES
dc.subject.mesh	Medical Subject Headings::Anatomy::Cells::Stem Cells::Multipotent Stem Cells::Mesenchymal Stromal Cells	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Biological Processes::Regeneration	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Biological Processes::Regeneration::Wound Healing	es_ES
dc.subject.mesh	Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation	es_ES
dc.subject.mesh	Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases	es_ES
dc.subject.mesh	Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans	es_ES
dc.title	The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology	en
dc.type	review article
dc.type.hasVersion	VoR
dspace.entity.type	Publication