Publication: Early predictors of corticosteroid response in acute severe autoimmune hepatitis: a nationwide multicenter study.
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Identifiers
Date
2022-04-02
Authors
Tellez, Luis
Sanchez Rodriguez, Eugenia
Rodriguez de Santiago, Enrique
Llovet, Laura
Gomez-Outomuro, Ana
Diaz-Fontenla, Fernando
Alvarez Lopez, Patricia
Garcia-Eliz, Maria
Amaral, Carla
Sanchez-Torrijos, Yolanda
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Blackwell Publishing
Abstract
To assess whether corticosteroids improve prognosis in patients with AS-AIH, and to identify factors at therapy initiation and during therapy predictive of the response to corticosteroids. This was a retrospective cohort study including all patients with AS-AIH admitted to 13 tertiary centres from January 2002 to January 2019. The composite primary outcome was death or liver transplantation within 90 days of admission. Kaplan-Meier and Cox regression methods were used for data analysis. Of 242 consecutive patients enrolled (mean age [SD] 49.7 [16.8] years), 203 received corticosteroids. Overall 90-day transplant-free survival was 61.6% (95% confidence interval [CI] 55.4-67.7). Corticosteroids reduced the risk of a poor outcome (adjusted hazard ratio [HR] 0.25; 95% CI 0.2-0.4), but this treatment failed in 30.5%. An internally validated nomogram composed of older age, MELD, encephalopathy and ascites at the initiation of corticosteroids accurately predicted the response (C-index 0.82; [95% CI 0.8-0.9]). In responders, MELD significantly improved from days 3 to 14 but remained unchanged in non-responders. MELD on day 7 with a cut-off of 25 (sensitivity 62.5%[95% CI: 47.0-75.8]; specificity 95.2% [95% CI: 89.9-97.8]) was the best univariate predictor of the response. Prolonging corticosteroids did not increase the overall infection risk (adjusted HR 0.75; 95% CI 0.3-2.1). Older patients with high MELD, encephalopathy or ascites at steroid therapy initiation and during treatment are unlikely to show a favourable response and so prolonged therapy in these patients, especially if they are transplantation candidates, should be avoided.
Description
MeSH Terms
Brain diseases
Hepatitis, autoimmune
Humans
Prognosis
Retrospective studies
Severity of illness index
Hepatitis, autoimmune
Humans
Prognosis
Retrospective studies
Severity of illness index
DeCS Terms
Encefalopatías
Estudios retrospectivos
Hepatitis autoinmune
Pronóstico
Índice de severidad de la enfermedad
Estudios retrospectivos
Hepatitis autoinmune
Pronóstico
Índice de severidad de la enfermedad
CIE Terms
Keywords
Acute disease, Adolescent, Adrenal cortex hormones, Ascites
Citation
Téllez L, Sánchez Rodríguez E, Rodríguez de Santiago E, Llovet L, Gómez-Outomuro A, Díaz-Fontenla F, et al. Early predictors of corticosteroid response in acute severe autoimmune hepatitis: a nationwide multicenter study. Aliment Pharmacol Ther. 2022 Jul;56(1):131-143