Oral Mucositis: Melatonin Gel an Effective New Treatment.

Abdel Moneim, Ahmed Esmat; Guerra-Librero, Ana; Florido, Javier; Shen, Ying-Qiang; Fernandez-Gil, Beatriz; Acuña-Castroviejo, Darío; Escames, Germaine

Publication:
Oral Mucositis: Melatonin Gel an Effective New Treatment.

dc.contributor.author	Abdel Moneim, Ahmed Esmat
dc.contributor.author	Guerra-Librero, Ana
dc.contributor.author	Florido, Javier
dc.contributor.author	Shen, Ying-Qiang
dc.contributor.author	Fernandez-Gil, Beatriz
dc.contributor.author	Acuña-Castroviejo, Darío
dc.contributor.author	Escames, Germaine
dc.contributor.funder	Spanish Ministry of Economy and Competitivity (MINECO)
dc.contributor.funder	Carlos III Health Institute
dc.contributor.funder	University of Granada, Spain
dc.contributor.funder	Innovation, Science, and Business Council, Junta de Andalucía, Spain.
dc.date.accessioned	2023-01-25T09:45:59Z
dc.date.available	2023-01-25T09:45:59Z
dc.date.issued	2017-05-03
dc.description.abstract	The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, the role of melatonin in the treatment of mucositis has recently been investigated, and offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients' lives.
dc.description.sponsorship	Part of this study was partially funded by the following grants: SAF2009-14037 from the Spanish Ministry of Economy and Competitivity (MINECO), CB/10/00238 from the Carlos III Health Institute, GREIB.PT_2010_04 from the CEIBiotic Program of the University of Granada, Spain, and CTS-101 from the Innovation, Science, and Business Council, Junta de Andalucía, Spain. Finally, we wish to thank Michael O’Shea for proofreading the paper.
dc.description.version	Si
dc.identifier.citation	Abdel Moneim AE, Guerra-Librero A, Florido J, Shen YQ, Fernández-Gil B, Acuña-Castroviejo D, et al. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int J Mol Sci. 2017 May 7;18(5):1003.
dc.identifier.doi	10.3390/ijms18051003
dc.identifier.essn	1422-0067
dc.identifier.pmc	PMC5454916
dc.identifier.pmid	28481279
dc.identifier.pubmedURL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454916/pdf
dc.identifier.unpaywallURL	https://www.mdpi.com/1422-0067/18/5/1003/pdf
dc.identifier.uri	http://hdl.handle.net/10668/11181
dc.issue.number	5
dc.journal.title	International journal of molecular sciences
dc.journal.titleabbreviation	Int J Mol Sci
dc.language.iso	en
dc.organization	IBS
dc.page.number	20
dc.publisher	MDPI AG
dc.pubmedtype	Journal Article
dc.pubmedtype	Review
dc.relation.projectID	SAF2009-14037
dc.relation.projectID	CB/10/00238
dc.relation.projectID	GREIB.PT_2010_04
dc.relation.projectID	CTS-101
dc.relation.publisherversion	https://www.mdpi.com/resolver?pii=ijms18051003
dc.rights	Attribution 4.0 International
dc.rights.accessRights	open access
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	chemotherapy
dc.subject	management
dc.subject	melatonin
dc.subject	mucositis
dc.subject	pathophysiology
dc.subject	radiotherapy
dc.subject.decs	Animales
dc.subject.decs	Antioxidantes
dc.subject.decs	Estomatitis
dc.subject.decs	Geles
dc.subject.decs	Humanos
dc.subject.decs	Melatonina
dc.subject.mesh	Animals
dc.subject.mesh	Antioxidants
dc.subject.mesh	Gels
dc.subject.mesh	Humans
dc.subject.mesh	Melatonin
dc.subject.mesh	Stomatitis
dc.title	Oral Mucositis: Melatonin Gel an Effective New Treatment.
dc.type	research article
dc.type.hasVersion	VoR
dc.volume.number	18
dspace.entity.type	Publication