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Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs

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dc.contributor.authorde la Cruz-Ojeda, Patricia
dc.contributor.authorFlores-Campos, Rocío
dc.contributor.authorDios-Barbeito, Sandra
dc.contributor.authorNavarro-Villarán, Elena
dc.contributor.authorMuntané, Jordi
dc.contributor.authoraffiliation[de la Cruz-Ojeda,P; Flores-Campos,R; Dios-Barbeito,S; Navarro-Villarán,E; Muntané,J] Institute of Biomedicine of Seville (IBiS), Hospital University “Virgen del Rocío”/ CSIC/ University of Seville, Seville, Spain. [de la Cruz-Ojeda,P; Navarro-Villarán,E; Muntané,J] Networked Biomedical Research Center Hepatic and Digestive Diseases (CIBEREHD o Ciberehd), Institute of Health Carlos III, Madrid, Spain. [de la Cruz-Ojeda,P; Navarro-Villarán,E; Muntané,J] Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain. [Dios-Barbeito,S] Department of General Surgery, Hospital University “Virgen del Rocío”/ CSIC/ University of Seville/ IBiS, Seville, Spain.
dc.contributor.funderThis research was funded by the Institute of Health Carlos III (ISCiii) (PI19/01266) and Andalusian Ministry of Health (PI-0216-2020). P de la C-O was supported by the FPU predoctoral fellowship (FPU17/00026) from the Ministry of Education, Culture and Sports. E N-V was supported by the predoctoral i-PFIS IIS-enterprise contract in science and technologies in health (IFI18/00014) from the ISCiii. S D-B was supported by the “Rio Hortega” postdoctoral contract (CM19/00151) from the ISCiii. We thank the Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd), founded by the ISCIII and co-financed by European Regional Development Fund “A way to achieve Europe” ERDF for their financial support.
dc.date.accessioned2022-05-20T10:50:25Z
dc.date.available2022-05-20T10:50:25Z
dc.date.issued2021-06-10
dc.description.abstractNitric oxide (NO) has been identified and described as a dual mediator in cancer according to dose-, time- and compartment-dependent NO generation. The present review addresses the different epigenetic mechanisms, such as histone modifications and non-coding RNAs (ncRNAs), miRNA and lncRNA, which regulate directly or indirectly nitric oxide synthase (NOS) expression and NO production, impacting all hallmarks of the oncogenic process. Among lncRNA, HEIH and UCA1 develop their oncogenic functions by inhibiting their target miRNAs and consequently reversing the inhibition of NOS and promoting tumor proliferation. The connection between miRNAs and NO is also involved in two important features in cancer, such as the tumor microenvironment that includes key cellular components such as tumor-associated macrophages (TAMs), cancer associated fibroblasts (CAFs) and cancer stem cells (CSCs).es_ES
dc.description.versionYeses_ES
dc.identifier.citationde la Cruz-Ojeda P, Flores-Campos R, Dios-Barbeito S, Navarro-Villarán E, Muntané J. Role of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAs. Int J Mol Sci. 2021 Jun 10;22(12):6264es_ES
dc.identifier.doi10.3390/ijms22126264es_ES
dc.identifier.essn1422-0067
dc.identifier.pmcPMC8230456
dc.identifier.pmid34200849es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3656
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoen
dc.page.number21 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/12/6264/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHepatocarcinomaes_ES
dc.subjectmiRNAes_ES
dc.subjectNitric oxide synthasees_ES
dc.subjectlncRNAes_ES
dc.subjectTumor-associated macrophageses_ES
dc.subjectCancer associated fibroblastses_ES
dc.subjectCancer stem cellses_ES
dc.subjectMicroARNses_ES
dc.subjectÓxido nítrico sintasaes_ES
dc.subjectARN largo no codificantees_ES
dc.subjectMacrófagos asociados a tumoreses_ES
dc.subjectFibroblastos asociados al cánceres_ES
dc.subjectCélulas madre neoplásicases_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncodinges_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Nitric Oxidees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferationes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Amino Acid Sequence::Histone Codees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetices_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastices_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironmentes_ES
dc.titleRole of Nitric Oxide in Gene Expression Regulation during Cancer: Epigenetic Modifications and Non-Coding RNAses_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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