Publication: Eosinophil cationic protein is not only a distinctive eosinophil protein
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Date
2008-02
Authors
Monteseirín, J
Vega, A
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Publisher
British Thoracic Society (BTS)
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Abstract
We read with interest the article by Qiu et al (Thorax 2007;62:475–82). In this paper, neutrophils and eosinophils were identified using mouse anti-human neutrophil elastase and anti-eosinophil cationic protein (ECP), both monoclonal antibodies (mAbs). mAbs against ECP have been used to detect total eosinophils, but immunostaining techniques evidenced that the number of ECP+ cells was higher than the number of eosinophils.1 Recent studies show that ECP is not only a distinctive eosinophil protein, but has been found in neutrophils.1–3
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MeSH Terms
Medical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Asthma
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Ribonucleases::Endoribonucleases::Eosinophil Cationic Protein
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Granulocytes::Neutrophils
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Clinical Laboratory Techniques::Immunologic Tests::Immunoassay::Immunoenzyme Techniques::Enzyme-Linked Immunosorbent Assay
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Ribonucleases::Endoribonucleases::Eosinophil Cationic Protein
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Granulocytes::Neutrophils
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Clinical Laboratory Techniques::Immunologic Tests::Immunoassay::Immunoenzyme Techniques::Enzyme-Linked Immunosorbent Assay
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Keywords
eosinophils, neutrófilos, eusinófilos
Citation
Monteseirín J, Vega A. Eosinophil cationic protein is not only a distinctive eosinophil protein. Thorax. 2008 Feb;63(2):185; authors' reply 185.