Publication:
Incidence and risk factors for hypertension among HIV patients in rural Tanzania - A prospective cohort study.

dc.contributor.authorRodríguez-Arbolí, Eduardo
dc.contributor.authorMwamelo, Kim
dc.contributor.authorKalinjuma, Aneth Vedastus
dc.contributor.authorFurrer, Hansjakob
dc.contributor.authorHatz, Christoph
dc.contributor.authorTanner, Marcel
dc.contributor.authorBattegay, Manuel
dc.contributor.authorLetang, Emilio
dc.contributor.authorKIULARCO Study Group
dc.date.accessioned2023-01-25T09:43:52Z
dc.date.available2023-01-25T09:43:52Z
dc.date.issued2017-03-08
dc.description.abstractScarce data are available on the epidemiology of hypertension among HIV patients in rural sub-Saharan Africa. We explored the prevalence, incidence and risk factors for incident hypertension among patients who were enrolled in a rural HIV cohort in Tanzania. Prospective longitudinal study including HIV patients enrolled in the Kilombero and Ulanga Antiretroviral Cohort between 2013 and 2015. Non-ART naïve subjects at baseline and pregnant women during follow-up were excluded from the analysis. Incident hypertension was defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg on two consecutive visits. Cox proportional hazards models were used to assess the association of baseline characteristics and incident hypertension. Among 955 ART-naïve, eligible subjects, 111 (11.6%) were hypertensive at recruitment. Ten women were excluded due to pregnancy. The remaining 834 individuals contributed 7967 person-months to follow-up (median 231 days, IQR 119-421) and 80 (9.6%) of them developed hypertension during a median follow-up of 144 days from time of enrolment into the cohort [incidence rate 120.0 cases/1000 person-years, 95% confidence interval (CI) 97.2-150.0]. ART was started in 630 (75.5%) patients, with a median follow-up on ART of 7 months (IQR 4-14). Cox regression models identified age [adjusted hazard ratio (aHR) 1.34 per 10 years increase, 95% CI 1.07-1.68, p = 0.010], body mass index (aHR per 5 kg/m2 1.45, 95% CI 1.07-1.99, p = 0.018) and estimated glomerular filtration rate (aHR The prevalence and incidence of hypertension were high in our cohort. Traditional cardiovascular risk factors predicted incident hypertension, but no association was observed with immunological or ART status. These data support the implementation of routine hypertension screening and integrated management into HIV programmes in rural sub-Saharan Africa.
dc.identifier.doi10.1371/journal.pone.0172089
dc.identifier.essn1932-6203
dc.identifier.pmcPMC5342176
dc.identifier.pmid28273105
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342176/pdf
dc.identifier.unpaywallURLhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172089&type=printable
dc.identifier.urihttp://hdl.handle.net/10668/10941
dc.issue.number3
dc.journal.titlePloS one
dc.journal.titleabbreviationPLoS One
dc.language.isoen
dc.organizationHospital Universitario Virgen del Rocío
dc.page.numbere0172089
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAnti-Retroviral Agents
dc.subject.meshBody Mass Index
dc.subject.meshCohort Studies
dc.subject.meshFemale
dc.subject.meshGlomerular Filtration Rate
dc.subject.meshHIV Infections
dc.subject.meshHumans
dc.subject.meshHypertension
dc.subject.meshIncidence
dc.subject.meshKaplan-Meier Estimate
dc.subject.meshLongitudinal Studies
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProportional Hazards Models
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.subject.meshRural Population
dc.subject.meshTanzania
dc.subject.meshYoung Adult
dc.titleIncidence and risk factors for hypertension among HIV patients in rural Tanzania - A prospective cohort study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication

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