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Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.

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dc.contributor.authorFarzan, Niloufar
dc.contributor.authorVijverberg, Susanne J
dc.contributor.authorAndiappan, Anand K
dc.contributor.authorArianto, Lambang
dc.contributor.authorBerce, Vojko
dc.contributor.authorBlanca-Lopez, Natalia
dc.contributor.authorBisgaard, Hans
dc.contributor.authorBønnelykke, Klaus
dc.contributor.authorBurchard, Esteban G
dc.contributor.authorCampo, Paloma
dc.contributor.authorCanino, Glorisa
dc.contributor.authorCarleton, Bruce
dc.contributor.authorCeledón, Juan C
dc.contributor.authorChew, Fook Tim
dc.contributor.authorChiang, Wen Chin
dc.contributor.authorCloutier, Michelle M
dc.contributor.authorDaley, Denis
dc.contributor.authorDen-Dekker, Herman T
dc.contributor.authorDijk, F Nicole
dc.contributor.authorDuijts, Liesbeth
dc.contributor.authorFlores, Carlos
dc.contributor.authorForno, Erick
dc.contributor.authorHawcutt, Daniel B
dc.contributor.authorHernandez-Pacheco, Natalia
dc.contributor.authorde-Jongste, Johan C
dc.contributor.authorKabesch, Michael
dc.contributor.authorKoppelman, Gerard H
dc.contributor.authorManolopoulos, Vangelis G
dc.contributor.authorMelen, Erik
dc.contributor.authorMukhopadhyay, Somnath
dc.contributor.authorNilsson, Sara
dc.contributor.authorPalmer, Colin N
dc.contributor.authorPino-Yanes, Maria
dc.contributor.authorPirmohamed, Munir
dc.contributor.authorPotocnik, Uros
dc.contributor.authorRaaijmakers, Jan A
dc.contributor.authorRepnik, Katja
dc.contributor.authorSchieck, Maximilian
dc.contributor.authorSio, Yang Yie
dc.contributor.authorSmyth, Rosalind L
dc.contributor.authorSzalai, Csaba
dc.contributor.authorTantisira, Kelan G
dc.contributor.authorTurner, Steve
dc.contributor.authorvan-der-Schee, Marc P
dc.contributor.authorVerhamme, Katia M
dc.contributor.authorMaitland-van der Zee, Anke H
dc.date.accessioned2023-01-25T09:47:53Z
dc.date.available2023-01-25T09:47:53Z
dc.date.issued2017-06-22
dc.description.abstractInternational collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed. PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.
dc.description.versionSi
dc.identifier.citationFarzan N, Vijverberg SJ, Andiappan AK, Arianto L, Berce V, Blanca-López N, et al. Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics. 2017 Jul;18(10):931-943
dc.identifier.doi10.2217/pgs-2017-0035
dc.identifier.essn1744-8042
dc.identifier.pmcPMC5967359
dc.identifier.pmid28639505
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967359/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5967359?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/11332
dc.issue.number10
dc.journal.titlePharmacogenomics
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationHospital Universitario Regional de Málaga
dc.page.number931-943
dc.provenanceRealizada la curación de contenido 06/05/2025
dc.publisherTaylor & Francis
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://www.tandfonline.com/doi/10.2217/pgs-2017-0035?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.rights.accessRightsRestricted Access
dc.subjectAsthma
dc.subjectChildren
dc.subjectConsortium
dc.subjectGenetics
dc.subjectPharmacogenomics
dc.subjectTreatment
dc.subject.decsFarmacogenética
dc.subject.decsAsma
dc.subject.decsCorticoesteroides
dc.subject.decsPredicción
dc.subject.meshAdministration, Inhalation
dc.subject.meshAnti-Asthmatic Agents
dc.subject.meshAsthma
dc.subject.meshChild
dc.subject.meshFemale
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshInternational Cooperation
dc.subject.meshMale
dc.subject.meshPharmacogenetics
dc.subject.meshPharmacogenomic Variants
dc.subject.meshRacial Groups
dc.subject.meshResearch Design
dc.subject.meshSurveys and Questionnaires
dc.subject.meshTreatment Outcome
dc.titleRationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number18
dspace.entity.typePublication

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