Publication:
Effect of Different Insulin Therapies on Obstetric-Fetal Outcomes.

dc.contributor.authorLópez-Tinoco, Cristina
dc.contributor.authorJiménez-Blázquez, José Luis
dc.contributor.authorLarrán-Escandón, Laura
dc.contributor.authorRoca-Rodríguez, María Del Mar
dc.contributor.authorBugatto, Fernando
dc.contributor.authorAguilar-Diosdado, Manuel
dc.date.accessioned2023-02-08T14:37:53Z
dc.date.available2023-02-08T14:37:53Z
dc.date.issued2019-11-27
dc.description.abstractTo evaluate the effectiveness of the different insulin therapies on obstetrics-fetal outcomes in women with pregestational diabetes mellitus. We enrolled 147 pregnant women with pre-existing type 1 or 2 diabetes mellitus. Clinical and biochemical parameters were analysed in relation to obstetric and fetal outcomes. 14.2% received treatment with Neutral Protamine Hagedorn insulin and short-acting insulin analogues; 19% with premixed human insulin; 40.1% with insulin glargine and lispro, 6.2% with detemir and aspart and 20% with continuous subcutaneous insulin infusion. All 5 types of treatment achieved a reduction of the mean HbA1c during pregnancy (p = 0.01). Pre-pregnancy care was carried out for 48% of patients. We found no statistically significant differences between the different insulin therapies and the obstetric-fetal outcomes. In conclusión, the different insulin therapies used in patients with pregestational diabetes mellitus does not seem to affect obstetric-fetal outcomes.
dc.identifier.doi10.1038/s41598-019-54164-4
dc.identifier.essn2045-2322
dc.identifier.pmcPMC6881342
dc.identifier.pmid31776421
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881342/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41598-019-54164-4.pdf
dc.identifier.urihttp://hdl.handle.net/10668/14757
dc.issue.number1
dc.journal.titleScientific reports
dc.journal.titleabbreviationSci Rep
dc.language.isoen
dc.organizationHospital Universitario Puerta del Mar
dc.organizationHospital Universitario Puerta del Mar
dc.page.number17650
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdult
dc.subject.meshDiabetes Mellitus
dc.subject.meshDiabetes Mellitus, Type 1
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshDiabetes, Gestational
dc.subject.meshDrug Combinations
dc.subject.meshFemale
dc.subject.meshGlycated Hemoglobin
dc.subject.meshHumans
dc.subject.meshInsulin
dc.subject.meshInsulin Detemir
dc.subject.meshInsulin Glargine
dc.subject.meshInsulin Lispro
dc.subject.meshInsulin, Long-Acting
dc.subject.meshPregnancy
dc.subject.meshPregnancy Outcome
dc.titleEffect of Different Insulin Therapies on Obstetric-Fetal Outcomes.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

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