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Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development.

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Date

2020-07-04

Authors

Saberi Hosnijeh, Fatemeh
Kolijn, Pieter M
Casabonne, Delphine
Nieters, Alexandra
Solans, Marta
Naudin, Sabine
Ferrari, Pietro
Mckay, James D
Weiderpass, Elisabete
Perduca, Vittorio

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Nature Publishing Group
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Abstract

Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL subtypes. Pre-diagnostic serum levels were measured for 517 BCL cases and 525 controls in a nested case-control study. The odds ratios of BCL were 6.2 in the highest versus lowest quartile for sCD23, 2.6 for sCD30, 4.2 for sCD27, and 2.6 for CXCL13. Higher levels of all markers were associated with increased risk of chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). Following mutual adjustment for the other immune markers, sCD23 remained associated with all subtypes and CXCL13 with FL and DLBCL. The associations of sCD23 with CLL and DLBCL and CXCL13 with DLBCL persisted among cases sampled > 9 years before diagnosis. sCD23 showed a good predictive ability (area under the curve = 0.80) for CLL, in particular among older, male participants. sCD23 and CXCL13 showed a mediating effect between body mass index (positive) and DLBCL risk, while CXCL13 contributed to the association between physical activity (inverse) and DLBCL. Our data suggest a role of B-cell activation in BCL development and a mediating role of the immune system for lifestyle factors.

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MeSH Terms

Antigens, CD
B-Lymphocytes
Biomarkers
Body Mass Index
Case-Control Studies
Chemokine CXCL13
Cohort Studies
Exercise
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Life Style
Lymphocyte Activation
Lymphoma, Follicular
Lymphoma, Large B-Cell, Diffuse
Male
Prospective Studies

DeCS Terms

Activación de linfocitos
Antígenos CD
Biomarcadores
Ejercicio físico
Estilo de vida
Leucemia linfocítica crónica de células B
Linfocitos B
Linfoma folicular
Linfoma de células B grandes
Quimiocina CXCL13
Índice de masa corporal

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Keywords

Body Mass Index, Case-Control Studies, Chemokine CXCL13, Cohort Studies, Exercise, Female

Citation

Saberi Hosnijeh F, Kolijn PM, Casabonne D, Nieters A, Solans M, Naudin S, et al. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development. Sci Rep. 2020 Aug 14;10(1):13814.