Publication:
Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial

Simple item page
dc.contributor.authorAzaryah, Hatim
dc.contributor.authorVerdejo-Román, Juan
dc.contributor.authorMartin-Pérez, Cristina
dc.contributor.authorGarcía-Santos, José Antonio
dc.contributor.authorMartínez-Zaldívar, Cristina
dc.contributor.authorTorres-Espínola, Francisco J.
dc.contributor.authorCampos, Daniel
dc.contributor.authorKoletzko, Berthold
dc.contributor.authorPérez-García, Miguel
dc.contributor.authorCatena, Andrés
dc.contributor.authorCampoy, Cristina
dc.contributor.authoraffiliation[Azaryah,H; García-Santos,JA; Martínez-Zaldívar,C; Torres-Espínola,FJ; Campos,D; Campoy,C] Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain. [Azaryah,H; García-Santos,JA; Martínez-Zaldívar,C; Torres-Espínola,FJ; Campos,D; Campoy,C] EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, Granada, Spain. [Verdejo-Román,J; Martin-Pérez,C; Pérez-García,M; Catena,A] Mind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, Granada, Spain. [García-Santos,JA; Campoy,C] Instituto de Investigación Biosanitaria de Granada (Ibs-GRANADA), Health Sciences Technological Park, Granada, Spain. [Koletzko,B] Ludwig-Maximiliams-Universität München, Dr. von Hauner Children’s Hospital, University of Munich Hospitals, Munich, Germany. [Campoy,C] Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, Madrid, Spain.
dc.contributor.funderThis work was supported by the Commission of the European Community’s 7th Framework Program (FP7/2008–2013), Grant agreement No. 212652 (NUTRIMENTHE Project); within the 6th Framework Program, Contract no. 007036 (EARNEST Project); and supported in part by the Commission of the European Community within the 5th Framework Program, Contract No. QLK1-CT-1999-00888 (NUHEAL EU Project). This publication is the work of the authors and does not necessarily reflect the views of the Commission of the European Community. The work of B.K. is supported by the European Research Council Advanced Grant ERC-2012-AdG-No.322605 META-GROWTH. J.V.-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33396). The funders had no role in the design, analysis or writing of this article.
dc.date.accessioned2022-09-19T07:49:23Z
dc.date.available2022-09-19T07:49:23Z
dc.date.issued2020-09-04
dc.description.abstractRecent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children's brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5-10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided into groups according to mother's supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, n = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, n = 24) (PFWE < 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother's FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´s cognitive processing.es_ES
dc.description.versionYeses_ES
dc.identifier.citationAzaryah H, Verdejo-Román J, Martin-Pérez C, García-Santos JA, Martínez-Zaldívar C, Torres-Espínola FJ, et al. Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial. Nutrients. 2020 Sep 4;12(9):2701es_ES
dc.identifier.doi10.3390/nu12092701es_ES
dc.identifier.essn2072-6643
dc.identifier.pmcPMC7551257
dc.identifier.pmid32899673es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4058
dc.journal.titleNutrients
dc.language.isoen
dc.page.number16 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/12/9/2701/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFish oiles_ES
dc.subjectFolatees_ES
dc.subjectPregnancyes_ES
dc.subjectBrain functiones_ES
dc.subjectResting-state functional neuroimaginges_ES
dc.subjectNeurodevelopmentes_ES
dc.subjectChildrenes_ES
dc.subjectMaternal nutritional physiological phenomenaes_ES
dc.subjectAceites de pescadoes_ES
dc.subjectÁcido fólicoes_ES
dc.subjectEmbarazoes_ES
dc.subjectNiñoes_ES
dc.subjectFenómenos fisiologicos nutricionales maternoses_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adultes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Braines_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Childes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child Developmentes_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Oils::Fish Oilses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studieses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaginges_ES
dc.subject.meshMedical Subject Headings::Check Tags::Malees_ES
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposurees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Maternal Nutritional Physiological Phenomenaes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Nerve Netes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancyes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysises_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysises_ES
dc.subject.meshMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::Leisure Activities::Relaxation::Restes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Pteridines::Pterins::Folic Acid::Tetrahydrofolateses_ES
dc.subject.meshMedical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplementses_ES
dc.titleEffects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Triales_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Azaryah_EffectsOf.pdf
Size:
1.41 MB
Format:
Adobe Portable Document Format
Description:
Artículo original
Download

Collections

Instituto de Investigación Biosanitaria de Granada (ibsGRANADA)

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía