Publication: Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH
dc.contributor.author | Ampuero, Javier | |
dc.contributor.author | Aller, Rocio | |
dc.contributor.author | Gallego-Duran, Rocio | |
dc.contributor.author | Crespo, Javier | |
dc.contributor.author | Calleja, Jose Luis | |
dc.contributor.author | Garcia-Monzon, Carmelo | |
dc.contributor.author | Gomez-Camarero, Judith | |
dc.contributor.author | Caballeria, Joan | |
dc.contributor.author | Lo-Iacono, Oreste | |
dc.contributor.author | Ibañez, Luis | |
dc.contributor.author | Garcia-Samaniego, Javier | |
dc.contributor.author | Albillos, Agustin | |
dc.contributor.author | Frances, Ruben | |
dc.contributor.author | Fernandez-Rodriguez, Conrado | |
dc.contributor.author | Diago, Moises | |
dc.contributor.author | Soriano, German | |
dc.contributor.author | Andrade, Raul J | |
dc.contributor.author | Latorre, Raquel | |
dc.contributor.author | Jorquera, Francisco | |
dc.contributor.author | Morillas, Rosa Maria | |
dc.contributor.author | Escudero, Desamparados | |
dc.contributor.author | Estevez, Pamela | |
dc.contributor.author | Hernandez-Guerra, Manuel | |
dc.contributor.author | Augustin, Salvador | |
dc.contributor.author | Bañales, Jesus | |
dc.contributor.author | Aspichueta, Patricia | |
dc.contributor.author | Benlloch, Salvador | |
dc.contributor.author | Rosales, Jose Miguel | |
dc.contributor.author | Salmeron, Javier | |
dc.contributor.author | Turnes, Juan | |
dc.contributor.author | Romero-Gomez, Manuel | |
dc.contributor.group | HEPAmet Registry | |
dc.date.accessioned | 2023-02-09T09:36:49Z | |
dc.date.available | 2023-02-09T09:36:49Z | |
dc.date.issued | 2020-03-06 | |
dc.description.abstract | Non-alcoholic fatty liver disease ( NAFLD ) could play a catalytic role in the development of metabolic comorbidities, although the magnitude of this effect in metabolically healthy patients with NAFLD remains unclear. We assessed the role of biopsy -proven NAFLD on the risk of developing type 2 diabetes mellitus (T2DM) and other metabolic comorbidities (arterial hypertension [AHT], and dyslipidemia ) in metabolically healthy patients . We included 178 metabolically healthy—defined by the absence of baseline T2DM, AHT, dyslipidemia — patients with biopsy -proven NAFLD from the HEPAmet Registry (N = 1,030). Hepamet fibrosis score (HFS), NAFLD fibrosis score, and Fibrosis -4 were calculated. Follow-up was computed from biopsy to the diagnosis of T2DM, AHT, or dyslipidemia .During a follow-up of 5.6 ± 4.4 years, T2DM occurred in 9% (16/178), AHT in 8.4% (15/178), low HDL in 9.6% (17/178), and hypertriglyceridemia in 23.6% (42/178) of patients . In multivariate analysis , significant fibrosis predicted T2DM and AHT. Independent variables related to T2DM appearance were significant fibrosis (HR 2.95; 95% CI 1.19–7.31; p = 0.019), glucose levels (p = 0.008), age (p = 0.007) and BMI (p = 0.039). AHT was independently linked to significant fibrosis (HR 2.39; 95% CI 1.14–5.10; p = 0.028), age (p = 0.0001), BMI (p = 0.006), glucose (p = 0.021) and platelets (p = 0.050). The annual incidence rate of T2DM was higher in patients with significant fibrosis (4.4 vs. 1.2 cases per 100 person -years), and increased in the presence of obesity , similar to AHT (4.6 vs. 1.1 cases per 100 person -years). HFS >0.12 predicted the risk of T2DM (25% [4/16] vs. HFS <0.12 4.5% [4/88]; logRank 6.658, p = 0.010).Metabolically healthy patients with NAFLD -related significant fibrosis were at greater risk of developing T2DM and AHT. HFS >0.12, but not NAFLD fibrosis score or Fibrosis -4, predicted the occurrence of T2DM. | |
dc.description.version | Si | |
dc.identifier.citation | Ampuero J, Aller R, Gallego-Durán R, Crespo J, Calleja JL, García-Monzón C, et al. Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH. J Hepatol. 2020 Jul;73(1):17-25. | |
dc.identifier.doi | 10.1016/j.jhep.2020.02.028 | |
dc.identifier.essn | 1600-0641 | |
dc.identifier.pmid | 32147361 | |
dc.identifier.unpaywallURL | ||
dc.identifier.uri | http://hdl.handle.net/10668/15927 | |
dc.issue.number | 3 | |
dc.journal.title | Journal of hepatology | |
dc.journal.titleabbreviation | J Hepatol | |
dc.language.iso | en | |
dc.organization | Hospital Universitario San Cecilio | |
dc.organization | Hospital Universitario Virgen de la Victoria | |
dc.organization | Hospital Costa del Sol | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.organization | Instituto de Biomedicina de Sevilla-IBIS | |
dc.organization | Hospital Universitario Virgen del Rocío | |
dc.page.number | 17-25 | |
dc.provenance | Realizada la curación de contenido 22/05/2025. | |
dc.publisher | Elsevier BV | |
dc.pubmedtype | research article | |
dc.relation.publisherversion | https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(20)30127-6 | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Arterial hypertension | |
dc.subject | Diabetes mellitus | |
dc.subject | Fibrosis | |
dc.subject | Hepamet score | |
dc.subject | NAFLD | |
dc.subject.decs | Enfermedad del hígado graso no alcohólico | |
dc.subject.decs | Fibrosis | |
dc.subject.decs | Dislipidemias | |
dc.subject.decs | Biopsia | |
dc.subject.decs | Diabetes Mellitus Tipo 2 | |
dc.subject.decs | Hipertrigliceridemia | |
dc.subject.mesh | Disease Progression | |
dc.subject.mesh | Female | |
dc.subject.mesh | Incidence | |
dc.subject.mesh | Longitudinal Studies | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Non-alcoholic Fatty Liver Disease | |
dc.subject.mesh | Liver Cirrhosis | |
dc.subject.mesh | Hypertension | |
dc.subject.mesh | Dyslipidemias | |
dc.title | Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 73 | |
dspace.entity.type | Publication |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- RISalud_Accesorestringido.pdf
- Size:
- 93.39 KB
- Format:
- Adobe Portable Document Format