Publication:
Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults.

dc.contributor.authorCordova, R
dc.contributor.authorKnaze, V
dc.contributor.authorViallon, V
dc.contributor.authorRust, P
dc.contributor.authorSchalkwijk, C G
dc.contributor.authorWeiderpass, E
dc.contributor.authorWagner, K-H
dc.contributor.authorMayen-Chacon, A-L
dc.contributor.authorAglago, E K
dc.contributor.authorDahm, C C
dc.contributor.authorOvervad, K
dc.contributor.authorTjønneland, A
dc.contributor.authorHalkjær, J
dc.contributor.authorMancini, F R
dc.contributor.authorBoutron-Ruault, M-C
dc.contributor.authorFagherazzi, G
dc.contributor.authorKatzke, V
dc.contributor.authorKühn, T
dc.contributor.authorSchulze, M B
dc.contributor.authorBoeing, H
dc.contributor.authorTrichopoulou, A
dc.contributor.authorKarakatsani, A
dc.contributor.authorThriskos, P
dc.contributor.authorMasala, G
dc.contributor.authorKrogh, V
dc.contributor.authorPanico, S
dc.contributor.authorTumino, R
dc.contributor.authorRicceri, F
dc.contributor.authorSpijkerman, A
dc.contributor.authorBoer, J
dc.contributor.authorSkeie, G
dc.contributor.authorRylander, C
dc.contributor.authorBorch, K B
dc.contributor.authorQuirós, J R
dc.contributor.authorAgudo, A
dc.contributor.authorRedondo-Sánchez, D
dc.contributor.authorAmiano, P
dc.contributor.authorGómez-Gómez, J-H
dc.contributor.authorBarricarte, A
dc.contributor.authorRamne, S
dc.contributor.authorSonestedt, E
dc.contributor.authorJohansson, I
dc.contributor.authorEsberg, A
dc.contributor.authorTong, T
dc.contributor.authorAune, D
dc.contributor.authorTsilidis, K K
dc.contributor.authorGunter, M J
dc.contributor.authorJenab, M
dc.contributor.authorFreisling, Heinz
dc.contributor.funderWorld Cancer Research Fund International
dc.contributor.funderFondation de France, FDF
dc.contributor.funderEuropean Commission
dc.contributor.funderInternational Agency for Research on Cancer.
dc.contributor.funderRegional Governments of Andalucía, Asturias, Basque Country, Murcia, Navarra, and the Catalan Institute of Oncology (Barcelona), Spain)
dc.contributor.funderCancer Research UK
dc.contributor.funderMedical Research Council
dc.date.accessioned2023-02-08T14:37:15Z
dc.date.available2023-02-08T14:37:15Z
dc.date.issued2019-10-23
dc.description.abstractAdvanced glycation end products (AGEs) can be formed in foods by the reaction of reducing sugars with proteins, and have been shown to induce insulin resistance and obesity in experimental studies. We examined the association between dietary AGEs intake and changes in body weight in adults over an average of 5 years of follow-up. A total of 255,170 participants aged 25-70 years were recruited in ten European countries (1992-2000) in the PANACEA study (Physical Activity, Nutrition, Alcohol, Cessation of smoking, Eating out of home in relation to Anthropometry), a sub-cohort of the EPIC (European Prospective Investigation into Cancer and Nutrition). Body weight was measured at recruitment and self-reported between 2 and 11 years later depending on the study center. A reference database for AGEs was used containing UPLC-MS/MS-measured Nε-(carboxymethyl)-lysine (CML), Nε-(1-carboxyethyl)-lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) in 200 common European foods. This reference database was matched to foods and decomposed recipes obtained from country-specific validated dietary questionnaires in EPIC and intake levels of CEL, CML, and MG-H1 were estimated. Associations between dietary AGEs intake and body weight change were estimated separately for each of the three AGEs using multilevel mixed linear regression models with center as random effect and dietary AGEs intake and relevant confounders as fixed effects. A one-SD increment in CEL intake was associated with 0.111 kg (95% CI 0.087-0.135) additional weight gain over 5 years. The corresponding additional weight gain for CML and MG-H1 was 0.065 kg (0.041-0.089) and 0.034 kg (0.012, 0.057), respectively. The top six food groups contributing to AGEs intake, with varying proportions across the AGEs, were cereals/cereal products, meat/processed meat, cakes/biscuits, dairy, sugar and confectionary, and fish/shellfish. In this study of European adults, higher intakes of AGEs were associated with marginally greater weight gain over an average of 5 years of follow-up.
dc.description.sponsorshipThis work was partially financially supported by the World Cancer Research Fund International (WCRF, Grant No. 2015/1391, MJ, VK, and HF) and the Fondation de France (FDF, Grant No. 00081166, HF, and FDF Grant No. 00089811, ALMC). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the following funders: Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF) (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland),World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS-ISCIII), the Regional Governments of Andalucía, Asturias, Basque Country, Murcia, Navarra, and the Catalan Institute of Oncology (Barcelona), Spain); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (UK).
dc.description.versionSi
dc.identifier.citationCordova R, Knaze V, Viallon V, Rust P, Schalkwijk CG, Weiderpass E, et al. Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults. Eur J Nutr. 2020 Oct;59(7):2893-2904
dc.identifier.doi10.1007/s00394-019-02129-8
dc.identifier.essn1436-6215
dc.identifier.pmid31701336
dc.identifier.unpaywallURLhttps://vbn.aau.dk/ws/files/461694069/Cordova_et_al_2019_dietary_intake_of_advanced_glycation_end_products.pdf
dc.identifier.urihttp://hdl.handle.net/10668/14654
dc.issue.number7
dc.journal.titleEuropean journal of nutrition
dc.journal.titleabbreviationEur J Nutr
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number2893-2904
dc.publisherSpringer Medizin
dc.pubmedtypeJournal Article
dc.relation.projectID2015/1391
dc.relation.projectID00081166
dc.relation.projectID00089811
dc.relation.projectID14136
dc.relation.projectIDC570/A16491
dc.relation.projectIDC8221/A19170
dc.relation.projectID1000143
dc.relation.projectIDMR/M012190/1
dc.relation.publisherversionhttps://dx.doi.org/10.1007/s00394-019-02129-8
dc.rights.accessRightsopen access
dc.subjectAdults
dc.subjectDietary advanced glycation end products
dc.subjectEurope
dc.subjectObesity
dc.subjectWeight change
dc.subject.decsAdulto
dc.subject.decsCromatografía liquida
dc.subject.decsDieta
dc.subject.decsEspectrometría de masas en tándem
dc.subject.decsEstudios prospectivos
dc.subject.decsEuropa (Continente)
dc.subject.decsHumanos
dc.subject.decsPeso corporal
dc.subject.decsProductos finales de glicación avanzada
dc.subject.meshAdult
dc.subject.meshBody Weight
dc.subject.meshChromatography, Liquid
dc.subject.meshDiet
dc.subject.meshEurope
dc.subject.meshGlycation End Products, Advanced
dc.subject.meshHumans
dc.subject.meshProspective Studies
dc.subject.meshTandem Mass Spectrometry
dc.titleDietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults.
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number59
dspace.entity.typePublication

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