Publication:
[Aetiology, outcomes and prognostic indicators of paediatric acute liver failure].

dc.contributor.authorGilbert Pérez, Juan José
dc.contributor.authorJordano Moreno, Belén
dc.contributor.authorRodríguez Salas, Mónica
dc.date.accessioned2023-01-25T09:44:56Z
dc.date.available2023-01-25T09:44:56Z
dc.date.issued2017-04-08
dc.description.abstractAcute liver failure (ALF) is a multisystem disease with severe impairment of liver function of acute onset. The Paediatric End-stage Liver Disease (PELD) score is used as a predictor of mortality in chronic liver disease, however experience is limited in ALF. To evaluate the aetiology and outcomes of children with ALF in a Children's Liver Transplant Centre, and to investigate the validity of PELD as a prognostic indicator. A retrospective study was conducted on patients diagnosed with ALF in our hospital from 2000 to 2013 using the criteria of the Paediatric ALF Study Group. The study included 49 patients with an age range 0-14years. The most frequent aetiologies were: indeterminate (36.7%) and metabolic (26.5%). Liver transplant (LT) was required by 42.8%, and there were 16.3% deaths. Patients with higher levels of bilirubin, INR, or encephalopathy were more likely to require a liver transplant, yielding an OR for INR 1.93. A cut-off of 27 in the PELD score according to the ROC curve showed a sensitivity of 86% and a specificity of 85%, predicting a worse outcome (AUC: 0.90; P ALF patients with a high PELD score and the presence of encephalopathy had worse outcomes. The PELD score could be a useful tool to establish the optimum time for inclusion in the transplant list, however further studies are still needed.
dc.identifier.doi10.1016/j.anpedi.2017.02.017
dc.identifier.essn2341-2879
dc.identifier.pmid28395968
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.anpedi.2017.02.017
dc.identifier.urihttp://hdl.handle.net/10668/11078
dc.issue.number2
dc.journal.titleAnales de pediatria
dc.journal.titleabbreviationAn Pediatr (Engl Ed)
dc.language.isoes
dc.organizationHospital Universitario Reina Sofía
dc.page.number63-68
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAcute liver failure
dc.subjectChildren
dc.subjectFallo hepático agudo
dc.subjectNiños
dc.subjectPELD
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshLiver Failure, Acute
dc.subject.meshLiver Transplantation
dc.subject.meshMale
dc.subject.meshPrognosis
dc.subject.meshRetrospective Studies
dc.subject.meshTreatment Outcome
dc.title[Aetiology, outcomes and prognostic indicators of paediatric acute liver failure].
dc.title.alternativeEtiología, resultados e indicadores pronósticos del fallo hepático agudo pediátrico.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number88
dspace.entity.typePublication

Files