Publication: Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer
Loading...
Identifiers
Date
2021-07-14
Authors
Boutriq, Soukaina
González-González, Alicia
Plaza-Andrades, Isaac
Laborda-Illanes, Aurora
Sánchez-Alcoholado, Lidia
Peralta-Linero, Jesús
Domínguez-Recio, María Emilia
Bermejo-Pérez, María José
Lavado-Valenzuela, Rocío
Alba, Emilio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies.
Description
MeSH Terms
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Estrogens
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Molecular Biology
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota
Medical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterus
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Estrogens
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Molecular Biology
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota
Medical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterus
DeCS Terms
Neoplasias endometriales
Microbioma gastrointestinal
Disbiosis
Inflamación
Prebióticos
Probióticos
Microbioma gastrointestinal
Disbiosis
Inflamación
Prebióticos
Probióticos
CIE Terms
Keywords
Endometrial cancer, Endometrial microbiome, Gut microbiome, Dysbiosis, Estrogen metabolism, Estrobolome, Inflammation, Antitumour treatment, Prebiotics, Probiotics
Citation
Boutriq S, González-González A, Plaza-Andrades I, Laborda-Illanes A, Sánchez-Alcoholado L, Peralta-Linero J, et aI. Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer. J Pers Med. 2021 Jul 14;11(7):659