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New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis

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dc.contributor.authorPérez-González, Noelia
dc.contributor.authorBozal-de Febrer, Nuria
dc.contributor.authorCalpena-Campmany, Ana C.
dc.contributor.authorNardi-Ricart, Anna
dc.contributor.authorRodríguez-Lagunas, María J.
dc.contributor.authorMorales-Molina, José A.
dc.contributor.authorSoriano-Ruiz, José L.
dc.contributor.authorFernández-Campos, Francisco
dc.contributor.authorClares-Naveros, Beatriz
dc.contributor.authoraffiliation[Pérez-González,N; Nardi-Ricart,A; Soriano-Ruiz,JL; Clares-Naveros,B] Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Campus of Cartuja, University of Granada, Granada, Spain. [Bozal-de Febrer,N] Department of Biology, Healthcare and the Environment, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. [Calpena-Campmany,AC] Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. [Calpena-Campmany,AC; Clares-Naveros,B] Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain. [Rodríguez-Lagunas,MJ] Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. [Rodríguez-Lagunas,MJ] Institute of Biomedicine, University of Barcelona, Barcelona, Spain. [Morales-Molina,JA] Department of Pharmacy, Torrecárdenas University Hospital, Almeria, Spain. [Fernández-Campos,F] Reig-Jofre Laboratories, Sant Joan Despi, Spain. [Clares-Naveros,B] Biosanitary Institute of Granada (ibs.GRANADA), Granada, Spain.
dc.contributor.funderThis research was funded by the Spanish National Research Council (CSIC), project no. 202080E231, and the Agreement with the University of Barcelona and the University of Granada (Official State Gazette 311, on 27 November 2020).
dc.date.accessioned2022-12-23T09:15:53Z
dc.date.available2022-12-23T09:15:53Z
dc.date.issued2021-12-12
dc.description.abstractVulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC.es_ES
dc.description.versionYeses_ES
dc.identifier.citationPérez-González N, Bozal-de Febrer N, Calpena-Campmany AC, Nardi-Ricart A, Rodríguez-Lagunas MJ, Morales-Molina JA, et al. New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis. Gels. 2021 Dec 12;7(4):259es_ES
dc.identifier.doi10.3390/gels7040259es_ES
dc.identifier.essn2310-2861
dc.identifier.pmcPMC8701247
dc.identifier.pmid34940319es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4540
dc.journal.titleGels
dc.language.isoen
dc.page.number22 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2310-2861/7/4/259es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectVulvovaginal candidiasises_ES
dc.subjectAntifungal therapyes_ES
dc.subjectCaspofungines_ES
dc.subjectVaginal mucosal deliveryes_ES
dc.subjectMucoadhesive hydrogeles_ES
dc.subjectThermoreversible hydrogeles_ES
dc.subjectCandidiasis vulvovaginales_ES
dc.subjectAntifúngicoses_ES
dc.subjectCaspofunginaes_ES
dc.subjectHidrogeleses_ES
dc.subjectPruritoes_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Womenes_ES
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Mycoses::Candidiasis::Candidiasis, Vulvovaginales_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antifungal Agentses_ES
dc.subject.meshMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Biomedical and Dental Materials::Polymers::Polyethylene Glycols::Poloxameres_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Colloids::Gels::Hydrogelses_ES
dc.subject.meshMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Vaginal Diseases::Vaginal Dischargees_ES
dc.subject.meshMedical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Prurituses_ES
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Sensationes_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.titleNew Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasises_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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