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Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients.

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Date

2018-03-16

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Padilla-Galo, A
Olveira, C
Fernandez-de-Rota-Garcia, L
Marco-Galve, I
Plata, A J
Alvarez, A
Rivas-Ruiz, F
Carmona-Olveira, A
Cebrian-Gallardo, J J
Martinez-Garcia, M A

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BioMed Central
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Some studies have reported a high prevalence of bronchiectasis in patients with uncontrolled asthma, but the factors associated with this condition are unknown. The objective of this study was to determine the prevalence of bronchiectasis in uncontrolled moderate-to-severe asthma and to identify risk factors and their correlation with bronchiectasis in these patients. This is a prospective study of data from consecutive patients with uncontrolled moderate-to-severe asthma. Diagnosis of bronchiectasis was based on high-resolution computed tomography. A prognostic score was developed using a logistic regression model, which was used to determine the factors associated with bronchiectasis. A total of 398 patients (60% with severe asthma) were included. The prevalence of bronchiectasis was 28.4%. The presence of bronchiectasis was associated with a higher frequency of chronic expectoration (OR, 2.95; 95% CI, 1.49-5.84; p = 0.002), greater severity of asthma (OR, 2.43; 95% CI, 1.29-4.57; p = 0.006), at least one previous episode of pneumonia (OR, 2.42; 95% CI, 1.03-5.69; p = 0.044), and lower levels of FeNO (OR, 0.98; 95% CI, 0.97-0.99; p = 0.016). The NOPES score was developed on the basis of these variables (FeNO[cut off point 20.5 ppb], Pneumonia, Expectoration and asthma Severity), and it ranges from 0 to 4 points, where 0 means "no risk" and 4 corresponds to "high risk". The NOPES score yielded an AUC-ROC of 70% for the diagnosis of bronchiectasis, with a specificity of 95%. Almost a third of the patients with uncontrolled moderate-to-severe asthma had bronchiectasis. Bronchiectasis was related to the severity of asthma, the presence of chronic expectoration, a previous history of pneumonia, and lower levels of FeNO. The NOPES score is an easy-to-use scoring system with a high prognostic value for bronchiectasis in patients with uncontrolled moderate-to-severe asthma.

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MeSH Terms

Adult
Aged
Asthma
Breath Tests
Bronchiectasis
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Male
Middle Aged
Prospective Studies
Severity of Illness Index
Sputum

DeCS Terms

Bronquiectasia
Asma
Neumonía
Factores de Riesgo
Área Bajo la Curva

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Keywords

Asthma, Bronchiectasis, NOPES, Prevalence, Risk factors

Citation

Padilla-Galo A, Olveira C, Fernández de Rota-Garcia L, Marco-Galve I, Plata AJ, Alvarez A, et al. Factors associated with bronchiectasis in patients with uncontrolled asthma; the NOPES score: a study in 398 patients. Respir Res. 2018 Mar 16;19(1):43