Publication: A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema.
dc.contributor.author | Doña, Inmaculada | |
dc.contributor.author | Torres, Maria Jose | |
dc.date.accessioned | 2023-02-09T10:43:39Z | |
dc.date.available | 2023-02-09T10:43:39Z | |
dc.date.issued | 2021-02-23 | |
dc.description.abstract | Hereditary angioedema (HAE) is a rare inherited chronic disease characterized by unpredictable recurrent attacks of cutaneous and submucosal swelling potentially involving airways, frequently upper ones, and compromising patient's life. This implies a serious health problem with significant disease burden and reduced life quality. This disease presents a great clinical variability and different endotypes, hampering diagnosis and requiring a personalized treatment. The primary mediator of swelling in most phenotypes is bradykinin, which increases vasodilation and vascular permeability by binding to the bradykinin B2 receptor. | |
dc.description.version | Si | |
dc.identifier.citation | Doña I, Torres MJ. A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema. Allergy. 2021 Jun;76(6):1619-1620 | |
dc.identifier.doi | 10.1111/all.14798 | |
dc.identifier.essn | 1398-9995 | |
dc.identifier.pmid | 33641193 | |
dc.identifier.uri | http://hdl.handle.net/10668/17250 | |
dc.issue.number | 6 | |
dc.journal.title | Allergy | |
dc.journal.titleabbreviation | Allergy | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Centro Andaluz de Nanomedicina y Biotecnología-BIONAND | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 1619-1620 | |
dc.provenance | Realizada la curación de contenido 05/03/2025 | |
dc.publisher | John Wiley and Sons | |
dc.pubmedtype | Editorial | |
dc.relation.publisherversion | https://doi.org/10.1111/all.14798 | |
dc.rights.accessRights | Restricted access | |
dc.subject | Vasodilation | |
dc.subject | Chronic Disease | |
dc.subject | Angioedemas, Hereditary | |
dc.subject | Quality of Life | |
dc.subject | Bradykinin | |
dc.subject | Cost of Illness | |
dc.subject | Capillary Permeability | |
dc.subject | Andalusian Center for Nanomedicine and Biotechnology-BIONAND | |
dc.subject.decs | Angioedemas hereditarios | |
dc.subject.decs | Costo de enfermedad | |
dc.subject.decs | Enfermedad crónica | |
dc.subject.decs | Vasodilatación | |
dc.subject.decs | Bradiquinina | |
dc.subject.decs | Permeabilidad capilar | |
dc.subject.mesh | Angioedemas, Hereditary | |
dc.subject.mesh | Antibodies, Monoclonal, Humanized | |
dc.subject.mesh | Complement C1 Inhibitor Protein | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Plasma Kallikrein | |
dc.title | A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema. | |
dc.type | research article | |
dc.volume.number | 76 | |
dspace.entity.type | Publication |
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