Publication:
A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema.

dc.contributor.authorDoña, Inmaculada
dc.contributor.authorTorres, Maria Jose
dc.date.accessioned2023-02-09T10:43:39Z
dc.date.available2023-02-09T10:43:39Z
dc.date.issued2021-02-23
dc.description.abstractHereditary angioedema (HAE) is a rare inherited chronic disease characterized by unpredictable recurrent attacks of cutaneous and submucosal swelling potentially involving airways, frequently upper ones, and compromising patient's life. This implies a serious health problem with significant disease burden and reduced life quality. This disease presents a great clinical variability and different endotypes, hampering diagnosis and requiring a personalized treatment. The primary mediator of swelling in most phenotypes is bradykinin, which increases vasodilation and vascular permeability by binding to the bradykinin B2 receptor.
dc.description.versionSi
dc.identifier.citationDoña I, Torres MJ. A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema. Allergy. 2021 Jun;76(6):1619-1620
dc.identifier.doi10.1111/all.14798
dc.identifier.essn1398-9995
dc.identifier.pmid33641193
dc.identifier.urihttp://hdl.handle.net/10668/17250
dc.issue.number6
dc.journal.titleAllergy
dc.journal.titleabbreviationAllergy
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationCentro Andaluz de Nanomedicina y Biotecnología-BIONAND
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number1619-1620
dc.provenanceRealizada la curación de contenido 05/03/2025
dc.publisherJohn Wiley and Sons
dc.pubmedtypeEditorial
dc.relation.publisherversionhttps://doi.org/10.1111/all.14798
dc.rights.accessRightsRestricted access
dc.subjectVasodilation
dc.subjectChronic Disease
dc.subjectAngioedemas, Hereditary
dc.subjectQuality of Life
dc.subjectBradykinin
dc.subjectCost of Illness
dc.subjectCapillary Permeability
dc.subjectAndalusian Center for Nanomedicine and Biotechnology-BIONAND
dc.subject.decsAngioedemas hereditarios
dc.subject.decsCosto de enfermedad
dc.subject.decsEnfermedad crónica
dc.subject.decsVasodilatación
dc.subject.decsBradiquinina
dc.subject.decsPermeabilidad capilar
dc.subject.meshAngioedemas, Hereditary
dc.subject.meshAntibodies, Monoclonal, Humanized
dc.subject.meshComplement C1 Inhibitor Protein
dc.subject.meshHumans
dc.subject.meshPlasma Kallikrein
dc.titleA new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema.
dc.typeresearch article
dc.volume.number76
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
RISalud_Accesorestringido.pdf
Size:
93.39 KB
Format:
Adobe Portable Document Format