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No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson's disease.

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dc.contributor.authorKim, Jonggeol Jeffrey
dc.contributor.authorBandres-Ciga, Sara
dc.contributor.authorBlauwendraat, Cornelis
dc.contributor.authorGan-Or, Ziv
dc.contributor.funderIntramural Research Programs of the National Institute of Neurological Disorders and Stroke (NINDS)
dc.contributor.funderNational Institute on Aging (NIA)
dc.contributor.funderNational Institutes of Health, Department of Health and Human Services
dc.contributor.funderDepartment of Defense
dc.contributor.groupInternational Parkinson's Disease Genomics Consortium
dc.date.accessioned2023-02-08T14:38:07Z
dc.date.available2023-02-08T14:38:07Z
dc.date.issued2019-11-07
dc.description.abstractMultiple genes have been implicated in Parkinson's disease (PD), including causal gene variants and risk variants typically identified using genome-wide association studies. Variants in the alcohol dehydrogenase genes ADH1C and ADH1B are among the genes that have been associated with PD, suggesting that this family of genes may be important in PD. As part of the International Parkinson's Disease Genomics Consortium's efforts to scrutinize previously reported risk factors for PD, we explored genetic variation in the alcohol dehydrogenase genes ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, and ADH7 using imputed genome-wide association study data from 15,097 cases and 17,337 healthy controls. Rare-variant association tests and single-variant score tests did not show any statistically significant association of alcohol dehydrogenase genetic variation with the risk for PD.
dc.description.sponsorshipThis work was supported in part by the Intramural Research Programs of the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), and the National Institute of Environmental Health Sciences both part of the National Institutes of Health, Department of Health and Human Services; project numbers 1ZIA-NS003154, Z01-AG000949–02 and Z01-ES101986. In addition, this work was supported by the Department of Defense (award W81XWH-09–2-0128), and The Michael J Fox Foundation for Parkinson’s Research. Ziv Gan-Or is supported by grants from the Michael J. Fox Foundation, the Canadian Consortium on Neurodegeneration in Aging (CCNA), the Canadian Glycomics Network (GlycoNet), the Canada First Research Excellence Fund (CFREF) through the Healthy Brains for Healthy Lives (HBHL) program and Parkinson’s Canada. Ziv Gan-Or is also supported by Chercheurs-boursiers - Junior 1 Award from the Fonds de recherche du Québec Santé (FRQS) and Parkinson’s Quebec, and by New Investigator Award from Parkinson’s Canada.
dc.description.versionSi
dc.identifier.citationKim JJ, Bandres-Ciga S, Blauwendraat C; International Parkinson's Disease Genomics Consortium; Gan-Or Z. No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson's disease. Neurobiol Aging. 2020 Mar;87:140.e19-140.e22.
dc.identifier.doi10.1016/j.neurobiolaging.2019.11.006
dc.identifier.essn1558-1497
dc.identifier.pmcPMC7064412
dc.identifier.pmid31806158
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064412/pdf
dc.identifier.unpaywallURLhttps://www.sciencedirect.com/science/article/am/pii/S0197458019303951
dc.identifier.urihttp://hdl.handle.net/10668/14794
dc.journal.titleNeurobiology of aging
dc.journal.titleabbreviationNeurobiol Aging
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number140e19 - 140e22
dc.provenanceRealizada la curación de contenido 15/07/2024
dc.publisherElsevier Inc.
dc.pubmedtypeCase Reports
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Intramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeResearch Support, U.S. Gov't, Non-P.H.S.
dc.relation.projectID1ZIA-NS003154
dc.relation.projectIDZ01-AG000949–02
dc.relation.projectIDZ01-ES101986
dc.relation.projectIDW81XWH-09–2-0128
dc.relation.publisherversionhttps://linkinghub.elsevier.com/retrieve/pii/S0197-4580(19)30395-1
dc.rights.accessRightsRestricted Access
dc.subjectADH1C
dc.subjectAlcohol dehydrogenase
dc.subjectBurden tests
dc.subjectGenetics
dc.subjectParkinson's disease
dc.subjectRisk
dc.subject.decsAlcohol deshidrogenasa
dc.subject.decsEnfermedad de Parkinson
dc.subject.decsEstudio de asociación del genoma completo
dc.subject.decsResultados negativos
dc.subject.decsRiesgo
dc.subject.meshAlcohol Dehydrogenase
dc.subject.meshGenetic Variation
dc.subject.meshGenome-Wide Association Study
dc.subject.meshNegative Results
dc.subject.meshParkinson Disease
dc.subject.meshRisk
dc.titleNo genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson's disease.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number87
dspace.entity.typePublication

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